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<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Challenges in Infective Endocarditis</title>
<creator>Cahill, Thomas J.</creator>
<creator>Baddour, Larry M.</creator>
<creator>Habib, Gilbert</creator>
<creator>Hoen, Bruno</creator>
<creator>Salaün, Erwan</creator>
<creator>Pettersson, Gosta B.</creator>
<creator>Schaefers, Hans Joachim</creator>
<creator>Prendergast, Bernard D.</creator>
<contributor>Service de cardiologie ; Université de la Méditerranée - Aix-Marseille 2 - Assistance Publique - Hôpitaux de Marseille (APHM) - Hôpital de la Timone [CHU - APHM] (TIMONE)</contributor>
<contributor>Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) ; Centre National de la Recherche Scientifique (CNRS) - IFR48 - Institut National de la Santé et de la Recherche Médicale (INSERM) - Aix Marseille Université (AMU) - Institut de Recherche pour le Développement (IRD)</contributor>
<contributor>Service des maladies infectieuses ; CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>CHU Pontchaillou [Rennes]</contributor>
<description>International audience</description>
<source>ISSN: 0735-1097</source>
<source>Journal of the American College of Cardiology</source>
<publisher>Elsevier</publisher>
<identifier>hal-01489511</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01489511</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01489511</source>
<source>Journal of the American College of Cardiology, Elsevier, 2017, 69 (3), pp.325-344. 〈10.1016/j.jacc.2016.10.066〉</source>
<identifier>DOI : 10.1016/j.jacc.2016.10.066</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jacc.2016.10.066</relation>
<language>en</language>
<subject>[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Infective endocarditis is defined by a focus of infection within the heart and is a feared disease across the field of cardiology. It is frequently acquired in the health care setting, and more than one-half of cases now occur in patients without known heart disease. Despite optimal care, mortality approaches 30% at 1 year. The challenges posed by infective endocarditis are significant. It is heterogeneous in etiology, clinical manifestations, and course. Staphylococcus aureus, which has become the predominant causative organism in the developed world, leads to an aggressive form of the disease, often in vulnerable or elderly patient populations. There is a lack of research infrastructure and funding, with few randomized controlled trials to guide practice. Longstanding controversies such as the timing of surgery or the role of antibiotic prophylaxis have not been resolved. The present article reviews the challenges posed by infective endocarditis and outlines current and future strategies to limit its impact. (C) 2017 by the American College of Cardiology Foundation.</description>
<date>2017-01</date>
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