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<identifier>oai:HAL:hal-01506828v1</identifier>
<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Clinical epidemiology and resistance mechanisms of carbapenem-resistant Acinetobacter baumannii, French Guiana, 2008-2014.</title>
<creator>Mahamat, Aba</creator>
<creator>Bertrand, Xavier</creator>
<creator>Moreau, Brigitte</creator>
<creator>Hommel, Didier</creator>
<creator>Couppie, Pierre</creator>
<creator>Simonnet, Christine</creator>
<creator>Kallel, Hatem</creator>
<creator>Demar, Magalie</creator>
<creator>Djossou, Felix</creator>
<creator>Nacher, Mathieu</creator>
<contributor>Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)</contributor>
<contributor>Laboratoire Chrono-environnement (LCE) ; Université Bourgogne Franche-Comté (UBFC) - Université de Franche-Comté (UFC) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut de l’Élevage</contributor>
<contributor>Centre Hospitalier Andrée-Rosemond</contributor>
<contributor>Epidemiologie des Parasitoses Tropicales (EPaT Team) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Département de Biologie, Unité de Biochimie des Lipides et des Protéines ; Faculté des Sciences de Tunis</contributor>
<contributor> Écosystèmes amazoniens et pathologie tropicale [Cayenne, Guyane Française] ; Université de Guyane (UG)</contributor>
<contributor>Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie [Cayenne, Guyane Française] ; Centre Hospitalier de Cayenne Andrée Rosemon - Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)</contributor>
<contributor>Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française] ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Centre d'Investigation Clinique Antilles Guyane, INSERM CIC 1424 ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH Guyane) ; Centre hospitalier Andrée Rosemon (Cayenne)</contributor>
<description>International audience</description>
<source>ISSN: 0924-8579</source>
<source>International Journal of Antimicrobial Agents</source>
<publisher>Elsevier</publisher>
<identifier>hal-01506828</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01506828</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01506828</source>
<source>International Journal of Antimicrobial Agents, Elsevier, 2016, 48 (1), pp.51-5</source>
<identifier>PUBMED : 27236843</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27236843</relation>
<language>en</language>
<subject lang=en>Acinetobacter baumannii</subject>
<subject lang=en>Carbapenem-resistant</subject>
<subject lang=en>Epidemiology</subject>
<subject lang=en>Intensive care unit</subject>
<subject lang=en>Nosocomial</subject>
<subject lang=en>Outbreak</subject>
<subject>[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>This study investigated the clinical epidemiology and resistance mechanisms of Acinetobacter baumannii and characterised the clonal diversity of carbapenem-resistant A. baumannii (CRAB) during an ICU-associated outbreak at Cayenne Hospital, French Guiana. All non-duplicate A. baumannii isolates from 2008 to 2014 were tested for antibiotic susceptibility by disk diffusion. Multilocus sequence typing, pulsed-field gel electrophoresis (PFGE) and characterisation of carbapenemase-encoding genes were performed on CRAB. Of the 441 A. baumannii isolates, most were from males (54.0%) and were detected mainly from the ICU (30.8%) and medicine wards (21.8%). In the ICU, strains were mainly isolated from the respiratory tract (44.1%) and bloodstream (14.0%), whereas in medicine wards they mainly were from wound/drainage (36.5%) and bloodstream (25.0%). A. baumannii showed the greatest susceptibility to piperacillin/tazobactam (92.7%), imipenem (92.5%), colistin (95.6%) and amikacin (97.2%), being lower in the ICU and medicine wards compared with other wards. An outbreak of OXA-23-producing CRAB occurred in the 13-bed ICU in 2010. CRAB strains were more co-resistant to other antimicrobials compared with non-CRAB. Molecular genetics analysis revealed five sequence types [ST78, ST107 and ST642 and two new STs (ST830 and ST831)]. Analysis of PFGE profiles indicated cross-transmissions of CRAB within the ICU, between the ICU and one medicine ward during transfer of patients, and within that medicine ward. This study provides the first clinical and molecular data of A. baumannii from French Guiana and the Amazon basin. The ICU was the highest risk unit of this nosocomial outbreak of OXA-23-producing CRAB, which could subsequently disseminate within the hospital.</description>
<date>2016</date>
</dc>
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