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<title lang=en>Cervical intraepithelial neoplasia and invasive cancer risks in women infected with HIV in the French West Indies.</title>
<creator>Kadhel, Philippe</creator>
<creator>Multigner, Luc</creator>
<creator>Bardinet, F.</creator>
<creator>Goerger-Sow, Mt</creator>
<creator>Janky, Eustase</creator>
<contributor>Service de gynécologie-obstétrique ; Université des Antilles et de la Guyane (UAG) - CHU Pointe à Pitre</contributor>
<contributor>Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM) ; Université de Rennes 1 (UR1) - IFR140 - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<description>International audience</description>
<source>ISSN: 1464-2662</source>
<source>EISSN: 1468-1293</source>
<source>HIV Medicine</source>
<publisher>Wiley</publisher>
<identifier>hal-00682744</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00682744</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00682744</source>
<source>HIV Medicine, Wiley, 2012, 13 (1), pp.79-82. 〈10.1111/j.1468-1293.2011.00939.x〉</source>
<identifier>DOI : 10.1111/j.1468-1293.2011.00939.x</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1468-1293.2011.00939.x</relation>
<identifier>PUBMED : 21819528</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/21819528</relation>
<language>en</language>
<subject lang=en>Caribbean population</subject>
<subject lang=en>cervical intraepithelial neoplasia</subject>
<subject lang=en>cervical screening</subject>
<subject lang=en>HIV</subject>
<subject lang=en>uterine cervical neoplasms</subject>
<subject>[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>OBJECTIVE: The aim of the study was to assess whether HIV infection is associated with a higher risk of invasive cervical cancer (ICC). METHODS: We conducted a region-wide, population-based observational cohort study of 1232 HIV-infected women over the age of 15 years in Guadeloupe, a French Caribbean archipelago, during the period 1999-2006. The observed numbers of incident cases of cervical intraepithelial neoplasia (CIN) and ICC were compared with the expected numbers of cases based on the incidence rates for the general population, and the standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated. RESULTS: The incidence rate of CIN was higher in the HIV-infected women than in the general population for all grades (SIR 10.1, 95% CI 6.8-14.6 for CIN grade 1; SIR 9.9, 95% CI 6.1-15.3 for CIN grade 2; and SIR 5.2, 95% CI 3.4-7.7 for CIN grade 3). However, no increase in the risk of ICC was observed (SIR 1.7, 95% CI 0.3-4.9). CONCLUSIONS: Despite an increase in the occurrence of cervical cancer precursors, no increase in the risk of cervical cancer was found in a population of HIV-infected women who receive treatment for their infection and have access to ICC prevention services.</description>
<date>2012-01</date>
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