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<publisher>HAL CCSD</publisher>
<title lang=en>Constitutive calcium entry and cancer: updated views and insights.</title>
<creator>Mignen, Olivier</creator>
<creator>Constantin, Bruno</creator>
<creator>Potier-Cartereau, Marie</creator>
<creator>Penna, Aubin</creator>
<creator>Gautier, Mathieu</creator>
<creator>Guéguinou, Maxime</creator>
<creator>Renaudineau, Yves</creator>
<creator>Shoji, Kenji</creator>
<creator>Félix, Romain</creator>
<creator>Bayet, Elsa</creator>
<creator>Buscaglia, Paul</creator>
<creator>Debant, Marjolaine</creator>
<creator>Chantôme, Aurélie</creator>
<creator>Vandier, Christophe</creator>
<contributor>Génétique, génomique fonctionnelle et biotechnologies ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de Brest (UBO) - EFS</contributor>
<contributor>Network “Ion channels and Cancer-Canceropole Grand Ouest” [Nantes] (IC-CGO) ; Cancéropôle Grand-Ouest [Bretagne-Centre-Pays de Loire]</contributor>
<contributor>Signalisation et Transports Ioniques Membranaires (STIM) ; Université de Poitiers - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Nutrition, croissance et cancer (N2C) ; Université François Rabelais - Tours - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Laboratoire de Physiologie Cellulaire et Moléculaire [Amiens] (EA 4667) ; Université de Picardie Jules Verne (UPJV)</contributor>
<contributor> Immunologie et Pathologie (EA 2216) ; Université de Brest (UBO) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>This work was supported by la Ligue Contre le Cancer (comités des régions Bretagne, Pays de la Loire, Centre, and Poitou-Charentes), Region Centre (LIPIDS project of ARD2020-Biomédicaments), Inserm, CNRS, Cancéropôle Grand Ouest, the association “CANCEN”, Tours’ Hospital oncology association ACORT”, Fondation ARC, ANR (ANR-12-JSV2-0004-001), Biosit, University of Brest, University of Rennes 1, University of Poitiers, University of Tours and Roche-SFD.</contributor>
<description>International audience</description>
<source>ISSN: 0175-7571</source>
<source>European Biophysics Journal</source>
<publisher>Springer Verlag (Germany)</publisher>
<identifier>inserm-01526286</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01526286</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01526286/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01526286/file/EBJO-D-16-00056_R1-2%20%282%29.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-01526286</source>
<source>European Biophysics Journal, Springer Verlag (Germany), 2017, 46 (5), pp.395-413. 〈10.1007/s00249-017-1216-8〉</source>
<identifier>PUBMED : 28516266</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28516266</relation>
<identifier>DOI : 10.1007/s00249-017-1216-8</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1007/s00249-017-1216-8</relation>
<language>en</language>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Tight control of basal cytosolic Ca2+ concentration is essential for cell survival and to fine-tune Ca2+-dependent cell functions. A way to control this basal cytosolic Ca2+ concentration is to regulate membrane Ca2+ channels including store-operated Ca2+ channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca2+ channels involved. It is well accepted that, in response to cell stimulation, opening of these Ca2+ channels contributes to Ca2+ entry and the transient increase in cytosolic Ca2+ concentration involved in intracellular signaling. However, in various experimental conditions, Ca2+ entry and/or Ca2+ currents can be recorded at rest, without application of any experimental stimulation. This led to the proposition that some plasma membrane Ca2+ channels are already open/activated in basal condition, contributing therefore to constitutive Ca2+ entry. This article focuses on direct and indirect observations supporting constitutive activity of channels belonging to the Orai and TRP families and on the mechanisms underlying their basal/constitutive activities.</description>
<date>2017-05-17</date>
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