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<title lang=en>Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?</title>
<creator>Oliveira-Junior, Raimundo Gonçalves</creator>
<creator>Thiéry, Valérie</creator>
<creator>Sergent, Odile</creator>
<creator>Chevanne, Martine</creator>
<creator>Picot, Laurent</creator>
<contributor>LIttoral ENvironnement et Sociétés - UMR 7266 (LIENSs) ; Université de La Rochelle (ULR) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>UNIVASF, Petrolina, Brazil ; universidade federal do vale do sao francisco (univasf)</contributor>
<contributor>Stress, membrane, signalisation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Ligue contre le Cancer 17</contributor>
<description>International audience</description>
<source>ISSN: 2141-2294</source>
<source>Journal of Oceanography and Marine Research</source>
<identifier>hal-01391001</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01391001</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01391001/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01391001/file/could-fucoxanthin-interaction-with-lipid-rafts-mediate-its-cytotoxicity-incancer-cells-.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01391001</source>
<source>Journal of Oceanography and Marine Research, 2016, 4 (1), pp.1000144. 〈10.4172/jomr.1000144 〉</source>
<identifier>DOI : 10.4172/jomr.1000144 </identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.4172/jomr.1000144 </relation>
<language>en</language>
<subject lang=en>Pigment</subject>
<subject lang=en>Phytoplankton</subject>
<subject lang=en>Fucoxanthin</subject>
<subject lang=en>Lipid raft</subject>
<subject lang=en>Algae</subject>
<subject lang=en>Apoptosis</subject>
<subject lang=en>Cancer</subject>
<subject lang=en>Carotenoid</subject>
<subject>[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</subject>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Fucoxanthin is a carotenoid present in brown micro-and macro algae, that induces apoptosis or autophagy in cancer cells grown in vitro. In vivo studies confirmed its interest as a natural anticancer compound, as it exerts antitumoral, antimetastatic and antiangiogenic activities in animal models. Studies focused on the pharmacology of fucoxanthin in cancer cells and tumors have revealed that it affects a wide panel of cellular, molecular and tissular processes, suggesting that its biological activity may be related in part to a nonspecific integration in cell membranes, and possible interaction with lipid rafts. Thus, preliminary data confirming this interaction of fucoxanthin with lipid rafts were obtained in mast cells and hepatoma WIF-B9 cells. We here discuss this hypothesis, in view of the critical function of lipid rafts in cancer cell survival, invasivity and communication with the tumoral microenvironment.</description>
<date>2016</date>
</dc>
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