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<datestamp>2018-01-03</datestamp>
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<title lang=en>Constitutive calcium entry and cancer: updated views and insights.</title>
<creator>Mignen, Olivier</creator>
<creator>Constantin, Bruno</creator>
<creator>Potier-Cartereau, Marie</creator>
<creator>Penna, Aubin</creator>
<creator>Gautier, Mathieu</creator>
<creator>Guéguinou, Maxime</creator>
<creator>Renaudineau, Yves</creator>
<creator>Shoji, Kenji F</creator>
<creator>Félix, Romain</creator>
<creator>Bayet, Elsa</creator>
<creator>Buscaglia, Paul</creator>
<creator>Debant, Marjolaine</creator>
<creator>Chantôme, Aurélie</creator>
<creator>Vandier, Christophe</creator>
<contributor>Lymphocyte B et Auto-immunité (LBAI) ; Université de Brest (UBO) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>INSERM UMR 1078 ; UMR INSERM1078</contributor>
<contributor>Faculté de Sciences fondamentales et appliquées - Université de Poitiers ; Université de Poitiers</contributor>
<contributor>Inserm UMR1069 ; Nutrition, croissance et cancer (N2C) ; Université François Rabelais - Tours - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université François Rabelais - Tours - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>IRSET-ESTER ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Laboratoire de Physiologie Cellulaire et Moléculaire [Amiens] (EA 4667) ; Université de Picardie Jules Verne (UPJV)</contributor>
<contributor>Laboratoire d'Immunologie et Immunothérapie [Brest] ; Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)</contributor>
<description>International audience</description>
<source>ISSN: 0175-7571</source>
<source>European Biophysics Journal</source>
<publisher>Springer Verlag (Germany)</publisher>
<identifier>hal-01528591</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01528591</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01528591</source>
<source>European Biophysics Journal, Springer Verlag (Germany), 2017, 46 (5), pp.395-413. 〈10.1007/s00249-017-1216-8〉</source>
<identifier>DOI : 10.1007/s00249-017-1216-8</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1007/s00249-017-1216-8</relation>
<identifier>PUBMED : 28516266</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28516266</relation>
<language>en</language>
<subject lang=en>Orai</subject>
<subject lang=en>SPCA</subject>
<subject lang=en>Cancer</subject>
<subject lang=en>Constitutive/basal Ca2+ entry</subject>
<subject lang=en>TRP</subject>
<subject lang=en>STIM</subject>
<subject>[SDV.IMM] Life Sciences [q-bio]/Immunology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Tight control of basal cytosolic Ca(2+) concentration is essential for cell survival and to fine-tune Ca(2+)-dependent cell functions. A way to control this basal cytosolic Ca(2+) concentration is to regulate membrane Ca(2+) channels including store-operated Ca(2+) channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca(2+) channels involved. It is well accepted that, in response to cell stimulation, opening of these Ca(2+) channels contributes to Ca(2+) entry and the transient increase in cytosolic Ca(2+) concentration involved in intracellular signaling. However, in various experimental conditions, Ca(2+) entry and/or Ca(2+) currents can be recorded at rest, without application of any experimental stimulation. This led to the proposition that some plasma membrane Ca(2+) channels are already open/activated in basal condition, contributing therefore to constitutive Ca(2+) entry. This article focuses on direct and indirect observations supporting constitutive activity of channels belonging to the Orai and TRP families and on the mechanisms underlying their basal/constitutive activities.</description>
<date>2017-05-17</date>
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