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<datestamp>2018-01-16</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=eng>Cerebral and muscle microvascular oxygenation in children with sickle cell disease: Influence of hematology, hemorheology and vasomotion.</title>
<creator>Charlot, Keyne</creator>
<creator>Antoine-Jonville, Sophie</creator>
<creator>Moeckesch, Berenike</creator>
<creator>Jumet, Stéphane</creator>
<creator>Romana, Marc</creator>
<creator>Waltz, Xavier</creator>
<creator>Divialle-Doumdo, Lydia</creator>
<creator>Hardy-Dessources, Marie</creator>
<creator>Petras, Marie</creator>
<creator>Tressieres, Benoît</creator>
<creator>Tarer, Vanessa</creator>
<creator>Hue, Olivier</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Connes, Philippe</creator>
<contributor>Biologie intégrée du globule rouge ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Institut de recherche biomédicale des armées (IRBA) ; Service de Santé des Armées</contributor>
<contributor>Unité Transversale de la Drépanocytose ; Hôpital Ricou - CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Institut Universitaire de France (IUF) ; Ministère de l'Éducation nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)</contributor>
<contributor>Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ) ; Université Claude Bernard Lyon 1 (UCBL) - Université Jean Monnet [Saint-Étienne] (UJM) - Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])</contributor>
<contributor>This work was supported by the Region of Guadeloupe</contributor>
<description>International audience</description>
<source>ISSN: 1079-9796</source>
<source>EISSN: 1096-0961</source>
<source>Blood Cells, Molecules and Diseases</source>
<publisher>Elsevier</publisher>
<identifier>inserm-01519106</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01519106</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01519106/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01519106/file/2017%2C%20Charlot%20-%20Cerebral%20and%20muscle%20microvascular%20oxygenation%20in%20children%20with%20sickle%20celle%20disease.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-01519106</source>
<source>Blood Cells, Molecules and Diseases, Elsevier, 2017, 65, pp.23-28. 〈10.1016/j.bcmd.2017.03.015〉</source>
<identifier>DOI : 10.1016/j.bcmd.2017.03.015</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bcmd.2017.03.015</relation>
<identifier>PUBMED : 28411485</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28411485</relation>
<language>en</language>
<subject lang=en>Tissue oxygen index</subject>
<subject lang=en>Vasomotion</subject>
<subject lang=en>Near-infrared spectroscopy</subject>
<subject lang=en>Sickle cell disease</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The present study investigated cerebral and muscle hemoglobin oxygen saturation (tissue oxygen index, TOI) in children with sickle cell anemia (SS), sickle cell hemoglobin C disease (SC) and healthy children (AA). TOI was measured by near-infrared spectroscopy (NIRS) and spectral analysis of the TOI variability was used to assess flowmotion and vasomotion. Arterial oxyhemoglobin saturation (SpO2), hemorheological and hematological parameters were also measured in SS and SC children. Both TOI were lower in SS compared to both AA and SC children, with SC exhibiting lower values than AA children. Cerebral vasomotion expressed in absolute values was enhanced in SS compared to AA and SC children. Muscle vasomotion did not differ between the three groups. Hematocrit, SpO2 and red blood cell deformability were positively associated with cerebral TOI in SS children. We demonstrated that 1) cerebral and muscle TOI were markedly decreased in SS children while the decrease of TOI was milder in SC children, 2) cerebral TOI level was associated with several biological markers in SS children only and 3) cerebral vasomotion was enhanced in SS, possibly to counterbalance the effects of chronic cerebral hypoxia.</description>
<date>2017-04-04</date>
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