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<title lang=en>CMV+ Serostatus Associates Negatively with CD4:CD8 Ratio Normalization in Controlled HIV-Infected Patients on cART</title>
<creator>Poizot-Martin, Isabelle</creator>
<creator>Allavena, Clotilde</creator>
<creator>Duvivier, Claudine</creator>
<creator>Cano, Carla Eliana</creator>
<creator>Guillouet De Salvador, Francine</creator>
<creator>Rey, David</creator>
<creator>Dellamonica, Pierre</creator>
<creator>Cuzin, Lise</creator>
<creator>Cheret, Antoine</creator>
<creator>Hoen, Bruno</creator>
<contributor>Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM) ; Institut de Recherche pour le Développement (IRD) - Aix Marseille Université (AMU) - ORS PACA - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud )</contributor>
<contributor>Service des maladies infectieuses et tropicales [CHU Nantes] ; CHU Nantes</contributor>
<contributor>Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV) (EA 7327) ; Université Paris Descartes - Paris 5 (UPD5)</contributor>
<contributor>Centre d’Infectiologie Necker Pasteur ; Assistance publique - Hôpitaux de Paris (AP-HP) - Université Paris Descartes - Paris 5 (UPD5) - CHU Necker - Enfants Malades [AP-HP]</contributor>
<contributor>Service des maladies infectieuses ; CHU Nice - University Hospital</contributor>
<contributor>Les Hôpitaux Universitaires de Strasbourg (HUS)</contributor>
<contributor>Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps [Toulouse] ; Université Paul Sabatier - Toulouse 3 (UPS) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Laboratoire de Virologie [CHU Necker] ; Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Necker - Enfants Malades [AP-HP]</contributor>
<contributor>Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant ; Université Paris Descartes - Paris 5 (UPD5)</contributor>
<contributor>Service des maladies infectieuses ; CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>inserm-01418700</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01418700</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01418700/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01418700/file/journal.pone.0165774.PDF</identifier>
<source>http://www.hal.inserm.fr/inserm-01418700</source>
<source>PLoS ONE, Public Library of Science, 2016, 11 (11), pp.e0165774. 〈10.1371/journal.pone.0165774〉</source>
<identifier>DOI : 10.1371/journal.pone.0165774</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0165774</relation>
<identifier>PUBMED : 27824907</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27824907</relation>
<identifier>PUBMEDCENTRAL : PMC5100980</identifier>
<language>en</language>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Cytomegalovirus (CMV) infection is common among HIV-infected patients but its repercussion on the course of CD4+ and CD8+ T cells after cART initiation remains elusive. The French Dat'AIDS cohort enrolled 5,688 patients on first-line cART, from which we selected patients who achieved HIV suppression for at least 12 months without modification of cART, and for whom CMV serostatus was available. Five hundred and three patients fulfilled the selection criteria (74% male, median age 43 yrs, 15.5% CDC stage C), of whom 444 (88.3%) were seropositive for CMV (CMV+). Multivariate analyses using mixed-linear models adjusted for the time from HIV suppression, sex, age, transmission risk group, duration of HIV follow-up, the interaction between time from HIV suppression and CMV+ serol-ogy, and the nadir CD4 count revealed a negative correlation between CMV+ and CD4: CD8 ratio (coeff. =-0.16; p = 0.001). This correlation was also observed among patients displaying optimal CD4 recovery (!500 cells/mm3 at M12; coeff. =-0.24; p = 0.002). Hence, CMV+ serostatus antagonizes normalization of the CD4:CD8 ratio, although further analyses of the impact of co-morbidities that associate with CMV serostatus, like HCV infection, are needed to elucidate this antagonism formally. However, this might reflect a premature T cell senescence, thus advocating for a close monitoring of T cells in CMV co-infected patients. In addition, our results raise the question of the benefit of treatment for asymptomatic CMV co-infection in HIV-infected patients.</description>
<contributor>Dat’AIDS Study Group</contributor>
<date>2016-11-08</date>
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