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<title lang=en>Childhood exposure to polybrominated diphenyl ethers and neurodevelopment at six years of age</title>
<creator>Chevrier, Cécile</creator>
<creator>Warembourg, Charline</creator>
<creator>Maner-Idrissi, Gaïd Le</creator>
<creator>Lacroix, Agnès</creator>
<creator>Dardier, Virginie</creator>
<creator>Le Sourn-Bissaoui, Sandrine</creator>
<creator>Rouget, Florence</creator>
<creator>Monfort, Christine</creator>
<creator>Gaudreau, Eric</creator>
<creator>Mercier, Fabien</creator>
<creator>Bonvallot, Nathalie</creator>
<creator>Glorennec, Philippe</creator>
<creator>Muckle, Gina</creator>
<creator>Le Bot, Barbara</creator>
<creator>Cordier, Sylvaine</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Centre de Recherches en Psychologie Cognition et Communication. UHB (CRPCC EA 1285) ; Université de Bretagne Sud (UBS) - Université de Brest (UBO) - MEN : EA1285 - Université de Rennes 2 (UR2)</contributor>
<contributor>Réseau périnatal "Bien naître en Ille-et-Vilaine" ; Hôtel-Dieu - CHU Pontchaillou [Rennes]</contributor>
<contributor>Institut National de santé publique du Québec (INSPQ) ; Institut national de santé publique du Québec</contributor>
<contributor>École des Hautes Études en Santé Publique [EHESP] (EHESP)</contributor>
<contributor>Université Laval</contributor>
<description>International audience</description>
<source>ISSN: 0161-813X</source>
<source>NeuroToxicology</source>
<publisher>Elsevier</publisher>
<identifier>hal-01286255</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01286255</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01286255/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01286255/file/Childhood%20exposure%20to%20polybrominated%20diphenyl-accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01286255</source>
<source>NeuroToxicology, Elsevier, 2016, 54, pp.81-88. 〈10.1016/j.neuro.2016.03.002〉</source>
<identifier>DOI : 10.1016/j.neuro.2016.03.002</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuro.2016.03.002</relation>
<identifier>PUBMED : 26955917</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26955917</relation>
<language>en</language>
<subject lang=en>brominated flame retardant</subject>
<subject lang=en> childhood</subject>
<subject lang=en> exposure</subject>
<subject lang=en> Neurodevelopment</subject>
<subject lang=en> Pregnancy</subject>
<subject>[SDV.TOX] Life Sciences [q-bio]/Toxicology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Mixtures of polybrominated diphenyl ethers (PBDEs) are present in indoor environments. Studies of the developmental effects of exposure to these chemicals in large prospective mother-child cohorts are required, with data on prenatal exposure and long-term follow-up of the children. We aimed to investigate the relationship between prenatal and childhood exposure to PBDEs and neurodevelopment at the age of six years. We determined the levels of PBDEs and other neurotoxicants in cord blood and dust collected from the homes of children for 246 families included in the PELAGIE mother-child cohort in France. We assessed two cognitive domains of the six-year-old children using the Wechsler Intelligence Scale for Children-IV. Verbal comprehension scores were lower in children from homes with higher concentrations of BDE99 (βDetects < median_vs_NonDetects = −1.6; 95% CI: −6.1, 2.9; βDetects≥median_vs_NonDetects = −5.4; −9.9, −1.0; ptrend = 0.02) and of BDE209 (β2nd_vs₁st_tertile = −1.8; 95% CI: −6.1, 2.5; β3rd_vs₁st_tertile = −3.2; −7.5, 1.2; ptrend = 0.15) in dust, particularly for boys (ptrend = 0.02 and 0.04, respectively). Working memory scores seemed to be lower in children with higher BDE99 concentrations in dust (ptrend = 0.10). No association was observed with cord blood levels of BDE209. Our findings are in agreement with those of four previous studies suggesting adverse cognitive outcomes among children associated with early-life exposure to penta-BDE mixtures, and provide new evidence for the potential neurotoxicity of BDE209. Several countries are in the process of banning the use of PBDE mixtures as flame-retardants. However, these compounds are likely to remain present in the environment for a long time to come</description>
<date>2016</date>
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