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<title lang=en>The CD95/CD95L signaling pathway: A role in carcinogenesis.</title>
<creator>Fouqué, Amélie</creator>
<creator>Debure, Laure</creator>
<creator>Legembre, Patrick</creator>
<contributor>Death Receptors and Tumor Escape ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - CRLCC Eugène Marquis (CRLCC)</contributor>
<description>International audience</description>
<source>ISSN: 0006-3002</source>
<source>BBA - Biochimica et Biophysica Acta</source>
<publisher>Elsevier</publisher>
<identifier>hal-01061290</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061290</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061290/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061290/file/BBAreviewsoncancer-legembre-final.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061290</source>
<source>BBA - Biochimica et Biophysica Acta, Elsevier, 2014, 1846 (1), pp.130-141. 〈10.1016/j.bbcan.2014.04.007〉</source>
<identifier>DOI : 10.1016/j.bbcan.2014.04.007</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbcan.2014.04.007</relation>
<identifier>PUBMED : 24780723</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24780723</relation>
<language>en</language>
<subject lang=en>Apoptosis</subject>
<subject lang=en>Carcinogenesis</subject>
<subject lang=en>Cytokine</subject>
<subject lang=en>Fas</subject>
<subject lang=en>Inflammation</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Apoptosis is a fundamental process that contributes to tissue homeostasis, immune responses, and development. The receptor CD95, also called Fas, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance, and various lineages of malignant cells exhibit loss-of-function mutations in this pathway; therefore, CD95 was initially classified as a tumor suppressor gene. However, more recent data indicate that in different pathophysiological contexts, this receptor can transmit non-apoptotic signals, promote inflammation, and contribute to carcinogenesis. A comparison with the initial molecular events of the TNF-R signaling pathway leading to non-apoptotic, apoptotic, and necrotic pathways reveals that CD95 is probably using different molecular mechanisms to transmit its non-apoptotic signals (NF-κB, MAPK, and PI3K). As discussed in this review, the molecular process by which the receptor switches from an apoptotic function to an inflammatory role is unknown. More importantly, the biological functions of these signals remain elusive.</description>
<date>2014-08</date>
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