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<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>C2orf62 and TTC17 Are Involved in Actin Organization and Ciliogenesis in Zebrafish and Human</title>
<creator>Bontems, Franck</creator>
<creator>Fish, Richard J</creator>
<creator>Borlat, Irene</creator>
<creator>Lembo, Frédérique</creator>
<creator>Chocu, Sophie</creator>
<creator>Chalmel, Frédéric</creator>
<creator>Borg, Jean-Paul</creator>
<creator>Pineau, Charles</creator>
<creator>Neerman-Arbez, Marguerite</creator>
<creator>Bairoch, Amos</creator>
<creator>Lane, Lydie</creator>
<contributor>Département de science des protéines humaines [Genève] ; Université de Genève (UNIGE) - Faculté de médecine [Genève]</contributor>
<contributor>Department of Genetic Medicine and Development ; University of Geneva Medical School</contributor>
<contributor>Centre de Recherche en Cancérologie de Marseille (CRCM) ; Centre National de la Recherche Scientifique (CNRS) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut Paoli-Calmettes - Aix Marseille Université (AMU)</contributor>
<contributor>Institut Paoli Calmettes ; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Swiss Institute of Bioinformatics (SIB) ; Swiss Institute of Bioinformatics (SIB)</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>hal-00955242</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00955242</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00955242/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00955242/file/C2orf62_and_TTC17-accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00955242</source>
<source>PLoS ONE, Public Library of Science, 2014, 9 (1), pp.e86476. 〈10.1371/journal.pone.0086476〉</source>
<identifier>DOI : 10.1371/journal.pone.0086476</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0086476</relation>
<identifier>PUBMED : 24475127</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24475127</relation>
<language>en</language>
<subject>[SDV.GEN] Life Sciences [q-bio]/Genetics</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Vertebrate genomes contain around 20,000 protein-encoding genes, of which a large fraction is still not associated with specific functions. A major task in future genomics will thus be to assign physiological roles to all open reading frames revealed by genome sequencing. Here we show that C2orf62, a highly conserved protein with little homology to characterized proteins, is strongly expressed in testis in zebrafish and mammals, and in various types of ciliated cells during zebrafish development. By yeast two hybrid and GST pull-down, C2orf62 was shown to interact with TTC17, another uncharacterized protein. Depletion of either C2orf62 or TTC17 in human ciliated cells interferes with actin polymerization and reduces the number of primary cilia without changing their length. Zebrafish embryos injected with morpholinos against C2orf62 or TTC17, or with mRNA coding for the C2orf62 C-terminal part containing a RII dimerization/docking (R2D2) - like domain show morphological defects consistent with imperfect ciliogenesis. We provide here the first evidence for a C2orf62-TTC17 axis that would regulate actin polymerization and ciliogenesis.</description>
<date>2014</date>
</dc>
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