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<identifier>oai:HAL:hal-01545481v1</identifier>
<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Common SNPs of AmelogeninX (AMELX) and Dental Caries Susceptibility</title>
<creator>Gasse, B.</creator>
<creator>Grabar, S.</creator>
<creator>Lafont, A. G.</creator>
<creator>Quinquis, L.</creator>
<creator>Vital, S. Opsahl</creator>
<creator>Davit-Beal, T.</creator>
<creator>Moulis, E.</creator>
<creator>Chabadel, O.</creator>
<creator>Hennequin, M.</creator>
<creator>Courson, F.</creator>
<creator>Droz, D.</creator>
<creator>Vaysse, F.</creator>
<creator>Laboux, O.</creator>
<creator>Tassery, H.</creator>
<creator>Al-Hashimi, N.</creator>
<creator>Boillot, A.</creator>
<creator>Carel, J. C.</creator>
<creator>Treluyer, J. M.</creator>
<creator>Jeanpierre, M.</creator>
<creator>Beldjord, C.</creator>
<creator>Sire, J. Y.</creator>
<creator>Chaussain, C.</creator>
<contributor>Evolution et développement du squelette (EDS) ; Systématique, adaptation, évolution (SAE) ; Centre National de la Recherche Scientifique (CNRS) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Evolution Paris Seine ; Université des Antilles et de la Guyane (UAG) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Centre National de la Recherche Scientifique (CNRS) - Université des Antilles et de la Guyane (UAG) - Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA)</contributor>
<contributor>AP-HP [CRC 06063 CARIOGENE]</contributor>
<description>International audience</description>
<source>ISSN: 0022-0345</source>
<source>Journal of Dental Research</source>
<publisher>SAGE Publications (UK and US)</publisher>
<identifier>hal-01545481</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01545481</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01545481</source>
<source>Journal of Dental Research, SAGE Publications (UK and US), 2013, 92 (5), pp.418-424. 〈10.1177/0022034513482941〉</source>
<identifier>DOI : 10.1177/0022034513482941</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1177/0022034513482941</relation>
<language>en</language>
<subject lang=en>enamel</subject>
<subject lang=en> amelogenesis</subject>
<subject lang=en> genetic predisposition</subject>
<subject lang=en> mutation</subject>
<subject lang=en> clinical trial</subject>
<subject lang=en> social environment</subject>
<subject>[SDV.BID.EVO] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Genetic approaches have shown that several genes could modify caries susceptibility; AmelogeninX (AMELX) has been repeatedly designated. Here, we hypothesized that AMELX mutations resulting in discrete changes of enamel microstructure may be found in children with a severe caries phenotype. In parallel, possible AMELX mutations that could explain resistance to caries may be found in caries-free patients. In this study, coding exons of AMELX and exon-intron boundaries were sequenced in 399 individuals with extensive caries (250) or caries-free (149) individuals from nine French hospital groups. No mutation responsible for a direct change of amelogenin function was identified. Seven single-nucleotide polymorphisms (SNPs) were found, 3 presenting a high allele frequency, and 1 being detected for the first time. Three SNPs were located in coding regions, 2 of them being non-synonymous. Both evolutionary and statistical analyses showed that none of these SNPs was associated with caries susceptibility, suggesting that AMELX is not a gene candidate in our studied population.</description>
<date>2013-05</date>
</dc>
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