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<datestamp>2017-12-21</datestamp>
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<title lang=en>Effet des acides gras omega 3 sur la toxicité hépatique induite par l'éthanol</title>
<creator>Collin, Aurore</creator>
<creator>Podechard, Normand</creator>
<creator>Chevanne, Martine</creator>
<creator>Cassio, Doris</creator>
<creator>Kah, Olivier</creator>
<creator>Dimanche-Boitrel, Marie-Therese</creator>
<creator>Lagadic-Gossmann, Dominique</creator>
<creator>Sergent, Odile</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>Cahiers de l'Ireb</source>
<identifier>hal-01117633</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117633</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117633</source>
<source>Cahiers de l'Ireb, 2013, pp.35-40</source>
<language>fr</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>We have previously shown that primary rat hepatocyte treatment by n-3 polyunsaturated fatty acids (omega 3) gave opposite results concerning early ethanol cytotoxicity (only a 5-hours-intoxication period) depending on the tested omega 3 type. The aim of this study was to follow on experiments in other in vitro and in vivo models that allowed longer intoxication times with ethanol. When highly differentiated hepatocytes from WIF-B9 line were treated with ethanol for 4 days, docosahexaenoic acid (DHA) protected from ethanol-induced cell death and oxidative stress, whereas eicosapentaenoic acid (EPA) increased ethanol toxic effects. In vivo, Zebrafish larvae exhibited a similar behavior after 7 days of ethanol intoxication depending on the omega 3 introduced in the bath. Altogether, these data confirm differential effects for omega 3s even for longer exposure times with ethanol.</description>
<date>2013</date>
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