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<title lang=en>Epidemiology of and diagnostic strategies for toxoplasmosis.</title>
<creator>Robert-Gangneux, Florence</creator>
<creator>Dardé, Marie-Laure</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Université de Limoges (UNILIM)</contributor>
<contributor>Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC) (CNR Toxoplasmose-Toxoplasma BRC) ; CHU Limoges</contributor>
<contributor>Neuroépidémiologie Tropicale (NET) ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503) - Institut d'Epidémiologie Neurologique et de Neurologie Tropicale - CHU Limoges - Université de Limoges (UNILIM)</contributor>
<description>International audience</description>
<source>ISSN: 0893-8512</source>
<source>Clinical Microbiology Reviews</source>
<publisher>American Society for Microbiology</publisher>
<identifier>hal-00696903</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00696903</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00696903/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00696903/file/Epidemiologysur and_Diagnostic-accepted.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00696903</source>
<source>Clinical Microbiology Reviews, American Society for Microbiology, 2012, 25 (2), pp.264-96. 〈10.1128/CMR.05013-11〉</source>
<identifier>DOI : 10.1128/CMR.05013-11</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/CMR.05013-11</relation>
<identifier>PUBMED : 22491772</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22491772</relation>
<language>en</language>
<subject>[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Summary: The apicomplexan parasite Toxoplasma gondii was discovered a little over 100 years ago, but knowledge of its biological life cycle and its medical importance has grown in the last 40 years. This obligate intracellular parasite was identified early as a pathogen responsible for congenital infection, but its clinical expression and the importance of reactivations of infections in immunocompromised patients were recognized later, in the era of organ transplantation and HIV infection. Recent knowledge of host cell-parasite interactions and of parasite virulence has brought new insights into the comprehension of the pathophysiology of infection. In this review, we focus on epidemiological and diagnostic aspects, putting them in perspective with current knowledge of parasite genotypes. In particular, we provide critical information on diagnostic methods according to the patient's background and discuss the implementation of screening tools for congenital toxoplasmosis according to health policies.</description>
<date>2012-04</date>
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