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<title lang=en>Early diagnosis of NAFLD-NASH transition using mid infrared spectroscopy.</title>
<creator>Bensaid, Siouar</creator>
<creator>Kachenoura, Amar</creator>
<creator>Costet, Nathalie</creator>
<creator>De Ledinghen, Victor</creator>
<creator>Vergniol, Julien</creator>
<creator>Lainé, Fabrice</creator>
<creator>Turlin, Bruno</creator>
<creator>Tariel, Hugues</creator>
<creator>Senhadji, Lotfi</creator>
<contributor>Laboratoire Traitement du Signal et de l'Image (LTSI) ; Université de Rennes 1 (UR1) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Centre d ' investigation de la fibrose hépatique ; CHU Bordeaux [Bordeaux] - Hôpital Haut Lévêque</contributor>
<contributor>Physiopathologie du cancer du foie ; Université Bordeaux Segalen - Bordeaux 2 - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>CHU Bordeaux [Bordeaux]</contributor>
<contributor>Service des maladies du foie ; Université de Rennes 1 (UR1) - CHU Pontchaillou [Rennes]</contributor>
<contributor>Foie, métabolismes et cancer ; Université de Rennes 1 (UR1) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>DIAFIR</contributor>
<description>International audience</description>
<source>ISSN: 1557-170X</source>
<source>Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference</source>
<publisher>Institute of Electrical and Electronics Engineers (IEEE)</publisher>
<identifier>inserm-01476033</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01476033</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01476033/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01476033/file/EMBC_2016_CameraReady.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-01476033</source>
<source>Conference proceedings : .. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, Institute of Electrical and Electronics Engineers (IEEE), 2016, pp.3602-3605. 〈10.1109/EMBC.2016.7591507〉</source>
<identifier>DOI : 10.1109/EMBC.2016.7591507</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1109/EMBC.2016.7591507</relation>
<identifier>PUBMED : 28269075</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28269075</relation>
<language>en</language>
<subject lang=en> Correlation</subject>
<subject lang=en> Liver</subject>
<subject lang=en> Spectroscopy</subject>
<subject lang=en> Biomedical optical imaging</subject>
<subject lang=en> Optical sensors</subject>
<subject lang=en>Optical attenuators</subject>
<subject>[SDV.IB] Life Sciences [q-bio]/Bioengineering</subject>
<subject>[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Non-alcoholic fatty liver disease (NAFLD) is defined as an excessive accumulation of fat in the liver in the absence of excessive drinking of alcohol. Initially considered as benign and self-limited, NAFLD may progress to the malignant stage of non-alcoholic steatohepatitis (NASH) characterized by degenerate hepatocellular ballooning and lobular inflammation. NASH can lead to hepatic fibrosis and ultimately to cirrhosis and hepatocellular carcinoma. Unfortunately, the transition from NAFLD to NASH is difficult to detect so far. In this paper, we propose to evaluate the characterization of NASH using mid infrared fiber evanescent wave spectroscopy on blood serum. We used an heuristic variable selection method and a generalized linear model to classify NAFLD and NASH spectra. The obtained results proved that this technique is a promising non-invasive and simple diagnosis tool for NASH.</description>
<date>2016-08-16</date>
<contributor>ANR-12-TECS-0012, AMNIFIR, Analyse Médicale Non invasive et Immédiate par Fibre optique Infra Rouge pour la detection de maladies chroniques et de tumeurs(2012)</contributor>
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