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<publisher>HAL CCSD</publisher>
<title lang=en>Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study</title>
<creator>Renoux, Céline</creator>
<creator>Romana, Marc</creator>
<creator>Joly, Philippe</creator>
<creator>Ferdinand, Séverine</creator>
<creator>Faes, Camille</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Skinner, Sarah</creator>
<creator>Garnier, Nathalie</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Bertrand, Yves</creator>
<creator>Petras, Marie</creator>
<creator>Cannas, Giovanna</creator>
<creator>Divialle-Doumdo, Lydia</creator>
<creator>Nader, Elie</creator>
<creator>Cuzzubbo, Daniela</creator>
<creator>Lamarre, Yann</creator>
<creator>Gauthier, Alexandra</creator>
<creator>Waltz, Xavier</creator>
<creator>Kebaili, Kamila</creator>
<creator>Martin, Cyril</creator>
<creator>Hot, Arnaud</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Pialoux, Vincent</creator>
<creator>Connes, Philippe</creator>
<creator>Tayo, Bamidele O.</creator>
<contributor>Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Institut de recherche en informatique de Toulouse (IRIT) ; Institut National Polytechnique [Toulouse] (INP) - Université Toulouse 1 Capitole (UT1) - Université Toulouse 2 (UT2) - Université Paul Sabatier - Toulouse 3 (UPS) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Observatoire Régional de la Santé de la Guadeloupe ; Observatoire Régional de la Santé de la Guadeloupe</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP) ; Institut national de la recherche agronomique [Montpellier] (INRA Montpellier) - Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro) - Centre de Coopération Internationale en Recherche Agronomique pour le Développement (CIRAD) - Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Hôpital Edouard Herriot ; Hospices Civils de Lyon - Hôpital Edouard Herriot</contributor>
<contributor>Dynamique des Structures et Interactions des Macromolécules Biologiques- Pôle de La Réunion (DSIMB Réunion) ; Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB) ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de la Réunion (UR)</contributor>
<contributor>Institut d’Hémato-Oncologie Pédiatrique</contributor>
<contributor>Centre de Recherche et d'Innovation sur le Sport (EA647) (CRIS) ; Université Claude Bernard Lyon 1 (UCBL)</contributor>
<contributor>Service de Médecine Interne ; Hôpital Edouard Herriot</contributor>
<contributor>Laboratoire de Physiologie-Biologie du Sport ; Université d'Auvergne - Clermont-Ferrand I (UdA)</contributor>
<contributor>The authors have no support or funding to report.</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>hal-01669747</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01669747</identifier>
<source>https://hal.univ-antilles.fr/hal-01669747</source>
<source>PLoS ONE, Public Library of Science, 2016, 11 (6), pp.e0158182. 〈10.1371/journal.pone.0158182〉</source>
<identifier>DOI : 10.1371/journal.pone.0158182</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0158182</relation>
<identifier>PUBMED : 27355589</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27355589</relation>
<identifier>PUBMEDCENTRAL : PMC4927160</identifier>
<language>en</language>
<subject lang=en>Blood</subject>
<subject lang=en>Viscosity</subject>
<subject lang=en>Sickle cell disease</subject>
<subject lang=en>Multivariate analysis</subject>
<subject lang=en>Rheology</subject>
<subject lang=en>Patients</subject>
<subject lang=en>Aging</subject>
<subject lang=en>Pathology and laboratory medicine</subject>
<subject>[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>OBJECTIVES:Blood rheology plays a key role in the pathophysiology of sickle cell anaemia (SS) and sickle cell haemoglobin C disease (SC), but its evolution over the lifespan is unknown.MATERIALS AND METHODS:Blood viscosity, red blood cell (RBC) deformability and aggregation, foetal haemoglobin (HbF) and haematocrit were measured in 114 healthy individuals (AA), 267 SS (161 children + 106 adults) and 138 SC (74 children + 64 adults) patients.RESULTS:Our results showed that 1) RBC deformability is at its maximal value during the early years of life in SS and SC populations, mainly because HbF level is also at its peak, 2) during childhood and adulthood, hydroxycarbamide treatment, HbF level and gender modulated RBC deformability in SS patients, independently of age, 3) blood viscosity is higher in older SS and SC patients compared to younger ones and 4) haematocrit decreases as SS patients age.CONCLUSION:The hemorheological changes detected in older patients could play a role in the progressive development of several chronic disorders in sickle cell disease, whose prevalence increases with age. Retarding these age-related haemorheological impairments, by using suitable drugs, may minimize the risks of vaso-occlusive events and chronic disorders.</description>
<rights>http://creativecommons.org/licenses/by/</rights>
<date>2016-06-29</date>
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