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<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd> <responseDate>2018-01-15T18:34:51Z</responseDate> <request identifier=oai:HAL:inserm-00831715v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request> <GetRecord> <record> <header> <identifier>oai:HAL:inserm-00831715v1</identifier> <datestamp>2017-12-21</datestamp> <setSpec>type:ART</setSpec> <setSpec>subject:sdv</setSpec> <setSpec>collection:INSERM</setSpec> <setSpec>collection:UNIV-AG</setSpec> <setSpec>collection:IFR140</setSpec> <setSpec>openaire</setSpec> <setSpec>collection:UNIV-RENNES1</setSpec> <setSpec>collection:IRSET</setSpec> <setSpec>collection:IRSET-NEED</setSpec> <setSpec>collection:BIOSIT</setSpec> <setSpec>collection:UR1-UFR-SVE</setSpec> <setSpec>collection:STATS-UR1</setSpec> <setSpec>collection:UR1-HAL</setSpec> <setSpec>collection:EHESP</setSpec> <setSpec>collection:USPC</setSpec> <setSpec>collection:UR1-SDV</setSpec> <setSpec>collection:IRSET-6</setSpec> <setSpec>collection:UNIV-ANGERS</setSpec> </header> <metadata><dc> <publisher>HAL CCSD</publisher> <title lang=en>Effects of estradiol in adult neurogenesis and brain repair in zebrafish.</title> <creator>Diotel, Nicolas</creator> <creator>Vaillant, Colette</creator> <creator>Gabbero, Cyril</creator> <creator>Mironov, Svetlana</creator> <creator>Fostier, Alexis</creator> <creator>Gueguen, Marie-Madeleine</creator> <creator>Anglade, Isabelle</creator> <creator>Kah, Olivier</creator> <creator>Pellegrini, Elisabeth</creator> <contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor> <contributor>Différenciation sexuelle et ovogenèse ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor> <contributor>European project no 222719 (LIFECYCLE to OK); ANR NEED (CES 2008-011); Post-Grenelle de l'Environnement.</contributor> <description>International audience</description> <source>ISSN: 0018-506X</source> <source>EISSN: 1095-6867</source> <source>Hormones and Behavior</source> <publisher>Elsevier</publisher> <identifier>inserm-00831715</identifier> <identifier>http://www.hal.inserm.fr/inserm-00831715</identifier> <source>http://www.hal.inserm.fr/inserm-00831715</source> <source>Hormones and Behavior, Elsevier, 2013, 63 (2), pp.193-207. 〈10.1016/j.yhbeh.2012.04.003〉</source> <identifier>DOI : 10.1016/j.yhbeh.2012.04.003</identifier> <relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.yhbeh.2012.04.003</relation> <identifier>PUBMED : 22521210</identifier> <relation>info:eu-repo/semantics/altIdentifier/pmid/22521210</relation> <language>en</language> <subject lang=en>Aromatase B</subject> <subject lang=en>Brain repair</subject> <subject lang=en>Estrogen</subject> <subject lang=en>Lesion</subject> <subject lang=en>Neurogenesis</subject> <subject lang=en>Radial glial cells</subject> <subject lang=en>Zebrafish</subject> <subject lang=en>Teleost</subject> <subject>[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism</subject> <type>info:eu-repo/semantics/article</type> <type>Journal articles</type> <description lang=en>The brain of the adult teleost fish exhibits intense neurogenic activity and an outstanding capability for brain repair. Remarkably, the brain estrogen-synthesizing enzyme, aromatase B, is strongly expressed, particularly in adult fishes, in radial glial cells, which act as progenitors. Using zebrafish, we tested the hypothesis that estrogens affect adult neurogenesis and brain regeneration by modulating the neurogenic activity of radial glial cells. To investigate this, the estrogenic environment was modified through inhibition of aromatase activity, blockade of nuclear estrogen receptors, or estrogenic treatments. Estrogens significantly decreased cell proliferation and migration at the olfactory bulbs/telencephalon junction and in the mediobasal hypothalamus. It also appears that cell survival is reduced at the olfactory bulbs/telencephalon junction. We also developed a model of telencephalic lesion to assess the role of aromatase and estrogens in brain repair. Proliferation increased rapidly immediately after the lesion in the parenchyma of the injured telencephalon, while proliferation at the ventricular surface appeared after 48 h and peaked at 7 days. At this time, most proliferative cells express Sox2, however, none of these Sox2 positive cells correspond to aromatase B-positive radial glial cells. Interestingly, aromatase B expression was significantly reduced 48 h and 7 days after the injury, but surprisingly, at 72 h after lesion, aromatase B expression appeared de novo expressed in parenchyma cells, suggesting a role for this ectopic expression of aromatase in brain repair mechanisms. Altogether these data suggest that estrogens modulate adult, but not reparative neurogenesis, in zebrafish.</description> <date>2013-02</date> <contributor>European Project : 222719, EC:FP7:KBBE, FP7-KBBE-2007-2A, LIFECYCLE(2009)</contributor> <relation>info:eu-repo/grantAgreement/EC/FP7/222719/EU/Building a biological knowledge-base on fish lifecycles for competitive, sustainable European aquaculture/LIFECYCLE</relation> </dc> </metadata> </record> </GetRecord> </OAI-PMH>