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<datestamp>2018-01-11</datestamp>
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<title lang=en>Effects of 60-GHz Millimeter Waves on Neurite Outgrowth in PC12Cells Using High Content Screening</title>
<creator>Haas, Alexis</creator>
<creator>Le Page, Yann</creator>
<creator>Zhadobov, Maxim</creator>
<creator>Sauleau, Ronan</creator>
<creator>Le Dréan, Yves</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institut d'Electronique et de Télécommunications de Rennes (IETR) ; Université de Nantes (UN) - Université de Rennes 1 (UR1) - Institut National des Sciences Appliquées - Rennes (INSA Rennes) - CentraleSupélec - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>This study was supported by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES), OMCell project no. 2012-2-061.</contributor>
<description>International audience</description>
<source>ISSN: 0304-3940</source>
<source>Neuroscience Letters</source>
<publisher>Elsevier</publisher>
<identifier>hal-01281481</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01281481</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01281481/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01281481/file/Effects%20of%2060-GHz%20Millimeter%20Waves%20on%20Neurite.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01281481</source>
<source>Neuroscience Letters, Elsevier, 2016, 618, pp.58-65. 〈10.1016/j.neulet.2016.02.038〉</source>
<identifier>DOI : 10.1016/j.neulet.2016.02.038</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neulet.2016.02.038</relation>
<identifier>PUBMED : 26921450</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26921450</relation>
<language>en</language>
<subject lang=en>Electromagnetic field</subject>
<subject lang=en> Neurite Outgrowth</subject>
<subject lang=en> Neuronal differentiation</subject>
<subject lang=en> Neuron-like cell line</subject>
<subject>[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Technologies for wireless telecommunication systems using millimeter waves (MMW) will be widely deployed in the near future. Forthcoming applications in this band, especially around 60 GHz, are mainly developed for high data-rate local and body-centric telecommunications. At those frequencies, electromagnetic radiations have a very shallow penetration into biological tissues, making skin keratinocytes, and free nerve endings of the upper dermis the main targets of MMW. Only a few studies assessed the impact of MMW on neuronal cells, and none of them investigated a possible effect on neuronal differentiation. We used a neuron-like cell line (PC12), which undergoes neuronal differentiation when treated with the neuronal growth factor (NGF). PC12 cells were exposed at 60.4 GHz for 24 h, at an incident power density averaged over the cell monolayer of 10 mW/cm2. Using a large scale cell-by-cell analysis based on high-content screening microscopy approach, we assessed potential effects of MMW on PC12 neurite outgrowth and cytoskeleton protein expression. No differences were found in protein expression of the neuronal marker β3-Tubulin nor in internal expression control β-Tubulin. On the other hand, our data showed a slight increase, although insignificant, in neurite outgrowth, induced by MMW exposure. However, experimental controls demonstrated that this increase was related to heating</description>
<date>2016</date>
</dc>
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