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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Exacerbation of oxidative stress during sickle vaso-occlusive crisis is associated with decreased anti-band 3 autoantibodies rate and increased red blood cell-derived microparticle level: a prospective study</title>
<creator>Hierso, Régine</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Villaescusa, Rinaldo</creator>
<creator>Lalanne-Mistrih, Marie-Laure</creator>
<creator>Charlot, Keyne</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Tressieres, Benoît</creator>
<creator>Lamarre, Yann</creator>
<creator>Tarer, Vanessa</creator>
<creator>Garnier, Yohann</creator>
<creator>Arce Hernandez, Ada</creator>
<creator>Ferracci, Serge</creator>
<creator>Connes, Philippe</creator>
<creator>Romana, Marc</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<contributor>Biologie Intégrée du Globule Rouge ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre</contributor>
<contributor>Centre de référence maladies rares pour la drépanocytose aux Antilles-Guyane ; Centre Hospitalier et Universitaire de Pointe-à-Pitre</contributor>
<contributor>Institut d'hématologie et d'immunologie, La Havane</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Centre Hospitalo-Universitaire de Pointe-à-Pitre/Abymes</contributor>
<contributor>Institut Universitaire de France (IUF) ; Ministère de l'Éducation nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)</contributor>
<contributor>Part of this study was supported by the ‘CPER/Region Guadeloupe’, grant nr. J-2-1-J210002, by the PHRC-API 2012, by APL 2010-Recherche Clinique CHU Pointe-a-Pitre, and by the ‘Conseil Regional de la Guadeloupe’, fellow-ship to R. H., who also received supports from the association ‘Guadeloupe - Espoir - Drepanocytose’, Club Soroptimist de Pointe-a-Pitre, Semsamar Guadeloupe and Fondation Semsamar Solidarites Saint-Martin</contributor>
<description>International audience</description>
<source>ISSN: 0007-1048</source>
<source>EISSN: 1365-2141</source>
<source>British Journal of Haematology</source>
<publisher>Wiley</publisher>
<identifier>inserm-01476067</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01476067</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01476067/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01476067/file/2016%2C%20Hierso%20-%20Exacerbation%20of%20oxidative%20stress%20during%20sickle%20vaso-occlusive%20crisis.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-01476067</source>
<source>British Journal of Haematology, Wiley, 2016, 176 (5), pp.805-813. 〈10.1111/bjh.14476〉</source>
<identifier>DOI : 10.1111/bjh.14476</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/bjh.14476</relation>
<identifier>PUBMED : 27984639</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27984639</relation>
<language>en</language>
<subject lang=en>sickle cell anaemia</subject>
<subject lang=en>oxidative stress</subject>
<subject lang=en>painful vaso-occlusive crisis</subject>
<subject lang=en>microparticles</subject>
<subject lang=en>natural anti-band 3 antibodies</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>MR and MDHD contributed equally to this work. Summary Painful vaso-occlusive crisis, a hallmark of sickle cell anaemia, results from complex, incompletely understood mechanisms. Red blood cell (RBC) damage caused by continuous endogenous and exogenous oxidative stress may precipitate the occurrence of vaso-occlusive crises. In order to gain insight into the relevance of oxidative stress in vaso-occlusive crisis occurrence , we prospectively compared the expression levels of various oxidative markers in 32 adults with sickle cell anaemia during vaso-occlusive crisis and steady-state conditions. Compared to steady-state condition, plasma levels of free haem, advanced oxidation protein products and myeloperoxi-dase, RBC caspase-3 activity, as well as the concentrations of total, neutrophil-and RBC-derived microparticles were increased during vaso-occlusive crises, whereas the reduced glutathione content was decreased in RBCs. In addition, natural anti-band 3 autoantibodies levels decreased during crisis and were negatively correlated with the rise in plasma advanced oxidation protein products and RBC caspase-3 activity. These data showed an exacerbation of the oxidative stress during vaso-occlusive crises in sickle cell anaemia patients and strongly suggest that the higher concentration of harmful circulating RBC-derived microparticles and the reduced anti-band 3 autoantibodies levels may be both related to the recruitment of oxidized band 3 into membrane aggregates.</description>
<date>2016-12-16</date>
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