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<identifier>oai:HAL:hal-01668325v1</identifier>
<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Exacerbation of oxidative stress during sickle vaso-occlusive crisis is associated with decreased anti-band 3 autoantibodies rate and increased red blood cell-derived microparticle level: a prospective study</title>
<creator>Hierso, Régine</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Villaescusa, Rinaldo</creator>
<creator>Lalanne-Mistrih, Marie-Laure</creator>
<creator>Charlot, Keyne</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Tressieres, Benoît</creator>
<creator>Lamarre, Yann</creator>
<creator>Tarer, Vanessa</creator>
<creator>Garnier, Yohann</creator>
<creator>Hernandez, Ada Arce</creator>
<creator>Ferracci, Serge</creator>
<creator>Connes, Philippe</creator>
<creator>Romana, Marc</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<contributor>Biologie Intégrée du Globule Rouge ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Institut d'hématologie et d'immunologie, La Havane</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Biologie intégrée du globule rouge ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Dynamique des Structures et Interactions des Macromolécules Biologiques- Pôle de La Réunion (DSIMB Réunion) ; Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB) ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de la Réunion (UR)</contributor>
<contributor>Service d'Orthopédie et de Traumatologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre Hospitalo-Universitaire de Pointe-à-Pitre/Abymes</contributor>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<description>International audience</description>
<source>ISSN: 0007-1048</source>
<source>EISSN: 1365-2141</source>
<source>British Journal of Haematology</source>
<publisher>Wiley</publisher>
<identifier>hal-01668325</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668325</identifier>
<source>https://hal.univ-antilles.fr/hal-01668325</source>
<source>British Journal of Haematology, Wiley, 2017, 176 (5), pp.805 - 813. 〈10.1111/bjh.14476〉</source>
<identifier>DOI : 10.1111/bjh.14476</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/bjh.14476</relation>
<language>en</language>
<subject lang=en>microparticles</subject>
<subject lang=en> natural anti-band 3 antibodies</subject>
<subject lang=en> oxidative stress</subject>
<subject lang=en> painful vaso-occlusive crisis</subject>
<subject lang=en> sickle cell anaemia</subject>
<subject>[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Painful vaso-occlusive crisis, a hallmark of sickle cell anaemia, results from complex, incompletely understood mechanisms. Red blood cell (RBC) damage caused by continuous endogenous and exogenous oxidative stress may precipitate the occurrence of vaso-occlusive crises. In order to gain insight into the relevance of oxidative stress in vaso-occlusive crisis occurrence, we prospectively compared the expression levels of various oxidative markers in 32 adults with sickle cell anaemia during vaso-occlusive crisis and steady-state conditions. Compared to steady-state condition, plasma levels of free haem, advanced oxidation protein products and myeloperoxidase, RBC caspase-3 activity, as well as the concentrations of total, neutrophil- and RBC-derived microparticles were increased during vaso-occlusive crises, whereas the reduced glutathione content was decreased in RBCs. In addition, natural anti-band 3 autoantibodies levels decreased during crisis and were negatively correlated with the rise in plasma advanced oxidation protein products and RBC caspase-3 activity. These data showed an exacerbation of the oxidative stress during vaso-occlusive crises in sickle cell anaemia patients and strongly suggest that the higher concentration of harmful circulating RBC-derived microparticles and the reduced anti-band 3 autoantibodies levels may be both related to the recruitment of oxidized band 3 into membrane aggregates.</description>
<date>2017-03</date>
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