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<publisher>HAL CCSD</publisher>
<title lang=en>Expression Patterns Suggest that Despite Considerable Functional Redundancy, Galectin-4 and-6 Play Distinct Roles in Normal and Damaged Mouse Digestive Tract</title>
<creator>Houzelstein, Denis</creator>
<creator>Reyes-Gomez, Edouard</creator>
<creator>Maurer, Marie</creator>
<creator>Netter, Pierre</creator>
<creator>Higuet, Dominique</creator>
<contributor>Evolution des Génomes Eucaryotes (EGE) ; Systématique, adaptation, évolution (SAE) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS) - Evolution Paris Seine ; Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Centre National de la Recherche Scientifique (CNRS) - Université des Antilles et de la Guyane (UAG) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Centre National pour la Recherche Scientifique (CNRS)</contributor>
<contributor> University Pierre et Marie Curie (UPMC)</contributor>
<contributor> GEFLUC Paris</contributor>
<description>International audience</description>
<source>ISSN: 0022-1554</source>
<source>Journal of Histochemistry and Cytochemistry</source>
<publisher>Histochemical Society</publisher>
<identifier>hal-01544764</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01544764</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01544764</source>
<source>Journal of Histochemistry and Cytochemistry, Histochemical Society, 2013, 61 (5), pp.348-361. 〈10.1369/0022155413478612〉</source>
<identifier>DOI : 10.1369/0022155413478612</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1369/0022155413478612</relation>
<language>en</language>
<subject lang=en>digestive tract</subject>
<subject lang=en> experimental colitis</subject>
<subject lang=en> galectin</subject>
<subject lang=en> lectin</subject>
<subject lang=en> mice</subject>
<subject lang=en> paralogues</subject>
<subject>[SDV.BID] Life Sciences [q-bio]/Biodiversity</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The galectin-4 protein is mostly expressed in the digestive tract and is associated with lipid raft stabilization, protein apical trafficking, wound healing, and inflammation. While most mammalian species, including humans, have a single Lgals4 gene, some mice have two paralogues: Lgals4 and Lgals6. So far, their significant similarities have hindered the analysis of their respective expression and function. We took advantage of two antibodies that discriminate between the galectin-4 and galectin-6 proteins to document their patterns of expression in the normal and the dextran sodium sulfate (DSS)-damaged digestive tract in the mouse. In the normal digestive tract, their pattern of expression from tongue to colon is quite similar, which suggests functional redundancy. However, the presence of galectin-4, but not galectin-6, in the lamina propria of the DSS-damaged colon, its association with luminal colonic bacteria, and differences in subcellular localization of these proteins suggest that they also have distinct roles in the normal and the damaged mouse digestive tract. Our results provide a rare example of ancestral and derived functions evolving after tandem gene duplication.</description>
<date>2013-05</date>
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