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<datestamp>2017-12-21</datestamp>
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<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia</title>
<creator>Connes, Philippe</creator>
<creator>Machado, Roberto</creator>
<creator>Hue, Olivier</creator>
<creator>Reid, Harvey</creator>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>UMR Inserm University of The French West Indies, Pointe-a-Pitre, Guadeloupe ; UMR Inserm, University of The French West Indies</contributor>
<contributor>Section of Pulmonary, Critical Care Medicine, Sleep and Allergy ; University of Illinois at Chicago (UIC)</contributor>
<contributor>Department of Basic Medical Sciences (Physiology Section), Faculty of Medical Sciences ; Department of Basic Medical Sciences (Physiology Section), Faculty of Medical Sciences</contributor>
<description>International audience</description>
<source>ISSN: 1386-0291</source>
<source>Clinical Hemorheology and Microcirculation</source>
<publisher>IOS Press</publisher>
<identifier>hal-01163966</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01163966</identifier>
<source>https://hal.univ-antilles.fr/hal-01163966</source>
<source>Clinical Hemorheology and Microcirculation, IOS Press, 2011, 48, pp.1-13. 〈10.3233/CH-2011-1465〉</source>
<identifier>DOI : 10.3233/CH-2011-1465</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.3233/CH-2011-1465</relation>
<language>en</language>
<subject lang=en>Sickle cell disease</subject>
<subject lang=en>exercise rehabilitation</subject>
<subject lang=en>exercise testing</subject>
<subject lang=en>clinical complications</subject>
<subject lang=en>physical fitness</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Sickle cell anemia (SCA or SS homozygous sickle cell disease) is an inherited blood disorder caused by single 12 nucleotide substitution in the -globin gene that renders their hemoglobin (HbS) much less soluble than normal hemoglobin 13 (HbA) when deoxygenated. The polymerization of HbS upon deoxygenation is the basic pathophysiologic event leading to 14 RBC sickling, hemolysis, vasoocclusion and ultimately to chronic organ damage. The metabolic changes imposed by exercise 15 may initiate sickling and vaso-occlusive episodes. Further, in patients with SCA, exercise limitation may be related to anemia 16 or chronic complications such as pulmonary vascular disease, congestive heart failure and chronic parenchymal lung disease. 17 Few studies have investigated the cardiorespiratory responses of patients with SCA during either symptom-limited maximal 18 exercise test on cyclo-ergometer or during a six minute walk test. Therefore, patients are advised to start exercise slowly and 19 progressively, to maintain adequate hydration during and after exercise, to avoid cold exposure or sudden change in temperature, 20 and to avoid sports associated with mechanical trauma. There are, however, lack of evidence to allow practitioners to prescribe 21 an exercise program for patients with SCA, and individuals are usually encouraged to exercise on a symptom-limited basis. 22 Finally, this review will also highlight the basic principles that are often used for exercise practice and could be used for exercise 23 prescription and rehabilitation in patients with sickle cell anemia.</description>
<date>2011</date>
</dc>
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