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<title lang=fr>Encephalitis due to Mycobacterium tuberculosis in France. [Encéphalites tuberculeuses en France]</title>
<creator>Honnorat, E.</creator>
<creator>De Broucker, T.</creator>
<creator>Mailles, A.</creator>
<creator>Stahl, J. P.</creator>
<creator>Michelet, Christian</creator>
<contributor>Department of Infectious Diseases ; CHU Grenoble</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>ISSN: 0399-077X</source>
<source>Médecine et Maladies Infectieuses</source>
<publisher>Elsevier Masson</publisher>
<identifier>hal-00874835</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00874835</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00874835</source>
<source>Médecine et Maladies Infectieuses, Elsevier Masson, 2013, 43 (6), pp.230-8. 〈10.1016/j.medmal.2013.05.003〉</source>
<identifier>DOI : 10.1016/j.medmal.2013.05.003</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.medmal.2013.05.003</relation>
<identifier>PUBMED : 23816146</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23816146</relation>
<language>en</language>
<subject lang=es>Encéphalite</subject>
<subject lang=es>Tuberculose</subject>
<subject>[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>PURPOSE: Two hundred and fifty-three patients were included in a study on the etiology of encephalitis, carried out in France in 2007. Tuberculosis was the second most frequently identified cause, after HSV and with the same number of cases as VZV. The authors report the specific features of patients presenting with tuberculosis encephalitis (TE). METHODS: TE patients were defined as patients presenting with encephalitis, with positive culture or PCR for Mycobacterium tuberculosis, or the association of clinical, biological, imaging, and epidemiological evidence (possible cases). Clinical, microbiological, and brain imaging data was analyzed and compared to that of other included patients. RESULTS: Twenty cases of TE were identified. The M/F sex-ratio was 1.5, the mean age 53 years. Four (20%) patients had a history of tuberculosis before the encephalitis. The median delay between the onset of general and neurological symptoms was significantly longer for tuberculosis cases than for others (10 days vs. 2; P<10(-10)). The median CSF protein level was significantly higher for tuberculosis cases (2.1 g/L vs. 0.8 g/L, P=0.002). CT scan and MRI were normal on admission for eight patients out of 17. Fourteen isolated strains of M. tuberculosis were susceptible to first-line anti-tuberculosis drugs and one was rifampicin-resistant. Six (33%) patients died during hospitalization and two were lost to follow-up. Ten out of 12 (78.6%) had persisting neurological symptoms on discharge. DISCUSSION: Despite non-multiresistant MT strains, the case fatality rate among TE patients was high in our series. Early brain imaging is poor contributive for the diagnosis of TE.</description>
<contributor>le comité de pilotage et groupe des investigateurs</contributor>
<date>2013-06</date>
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