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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease.</title>
<creator>Waltz, Xavier</creator>
<creator>Romana, Marc</creator>
<creator>Lalanne-Mistrih, Marie-Laure</creator>
<creator>Machado, Roberto, </creator>
<creator>Lamarre, Yann</creator>
<creator>Tarer, Vanessa</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Tressieres, Benoit</creator>
<creator>Divialle-Doumdo, Lydia</creator>
<creator>Petras, Marie</creator>
<creator>Maillard, Frederic</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Connes, Philippe</creator>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Laboratory of Excellence GR-Ex " The red cell : from genesis to death " ; PRES Sorbonne Paris Cité</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Section of Pulmonary, Critical Care Medicine, Sleep and Allergy ; University of Illinois at Chicago (UIC)</contributor>
<contributor>Service d'Orthopédie et de Traumatologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Service de Pédiatrie ; Hôpital Ricou - CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>This work was supported by the "Interregional Projet Hospitalier de Recherche Clinique" (PHRC). Funding for PhD student, X.W. was provided by the regional council of Guadeloupe.</contributor>
<description>International audience</description>
<source>ISSN: 0390-6078</source>
<source>EISSN: 1592-8721</source>
<source>Haematologica</source>
<publisher>Ferrata Storti Foundation</publisher>
<identifier>inserm-00838989</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00838989</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00838989/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00838989/file/Waltz_et_al._Ferrata_Storti_Foundation.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00838989</source>
<source>Haematologica, Ferrata Storti Foundation, 2013, 98 (7), pp.1039-44. 〈10.3324/haematol.2013.083576〉</source>
<identifier>DOI : 10.3324/haematol.2013.083576</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.3324/haematol.2013.083576</relation>
<identifier>PUBMED : 23539539</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23539539</relation>
<language>en</language>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57 with sickle cell anemia) at steady state. Hemoglobin oxygen saturation was measured before and immediately after the six-minute walk test. Blood samples were obtained on the same day to measure hematologic and hemorheological parameters. Exercise-induced hemoglobin oxygen desaturation was defined as a drop in hemoglobin oxygen saturation of 3% or more at the end of the six-minute walk test compared to resting levels. No children with sickle hemoglobin C disease, but approximately 50% of children with sickle cell anemia showed mild or moderate oxygen desaturation at rest, which was independently associated with the percentage of reticulocytes. Exercise-induced hemoglobin oxygen desaturation was observed in 18% of children with sickle hemoglobin C disease and 34% of children with sickle cell anemia, and was independently associated with the six-minute walk test, acute chest syndrome rate and the strength of red blood cell aggregates in children with sickle cell anemia. No association was found in children with sickle hemoglobin C disease between exercise-induced hemoglobin oxygen desaturation and the measured parameters. Hemoglobin oxygen desaturation at rest was common in children with sickle cell anemia but not in children with sickle hemoglobin C disease, and was mainly associated with greater hemolysis. Physiological strain during exercise and red blood cell aggregation properties may predict the occurrence of exercise-induced hemoglobin oxygen desaturation in children with sickle cell anemia.</description>
<date>2013-07</date>
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