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<title lang=en>Hypertensive disorders of pregnancy and gestational diabetes mellitus among French Caribbean women chronically exposed to chlordecone.</title>
<creator>Saunders, Lauren</creator>
<creator>Kadhel, Philippe</creator>
<creator>Costet, Nathalie</creator>
<creator>Rouget, Florence</creator>
<creator>Monfort, Christine</creator>
<creator>Thomé, Jean-Pierre</creator>
<creator>Guldner, Laurence</creator>
<creator>Cordier, Sylvaine</creator>
<creator>Multigner, Luc</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Service de gynécologie-obstétrique ; Université des Antilles et de la Guyane (UAG) - CHU Pointe à Pitre</contributor>
<contributor>Center for Analytical Research and Technology ; Université de Liège</contributor>
<contributor>Département santé environnement ; Institut de Veille Sanitaire</contributor>
<contributor>This study was made possible by the support of INSERM; Agence Nationale de la Recherche (Grant no. 06-PNRA-0011); Agence Française de Sécurité Sanitaire de l'Environnement et du Travail; Programme National de Recherche sur les Perturbateurs Endocriniens; Direction Générale de la Santé; and Institut de Veille Sanitaire. All authors saw and approved the final manuscript. The authors declare no conflict of interests. Luc Multigner and Sylvaine Cordier contributed equally to this work.</contributor>
<description>International audience</description>
<source>ISSN: 0160-4120</source>
<source>Environment International</source>
<publisher>Elsevier</publisher>
<identifier>hal-01061391</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061391</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061391/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061391/file/Saunders_et_al._Final_version_main_manuscript.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061391</source>
<source>Environment International, Elsevier, 2014, 68, pp.171-6. 〈10.1016/j.envint.2014.03.024〉</source>
<identifier>DOI : 10.1016/j.envint.2014.03.024</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envint.2014.03.024</relation>
<identifier>PUBMED : 24727072</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24727072</relation>
<language>en</language>
<subject lang=it>Chlordecone</subject>
<subject lang=it>Endocrine disruptor</subject>
<subject lang=it>Gestational diabetes</subject>
<subject lang=it>Gestational hypertension</subject>
<subject lang=it>Organochlorine pesticides</subject>
<subject lang=it>Preeclampsia</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Few studies have explored the consequences of environmental exposure to organochlorine pesticides for gestational hypertension (GH), preeclampsia (PE) and gestational diabetes mellitus (GDM). Chlordecone is a persistent organochlorine pesticide that was used intensively, and almost exclusively, in the French West Indies until 1993. We investigated the impact of prenatal exposure to chlordecone on the occurrence of GDM, GH and PE by studying 779 pregnant women enrolled in a prospective mother-child cohort (Timoun Study) in Guadeloupe between 2004 and 2007. Chlordecone exposure was determined by assaying maternal plasma and information about pregnancy complications was obtained from midwives, pediatricians and hospital medical records after delivery. The risks of GH (n=65), PE (n=31) and GDM (n=71) were estimated by multiple logistic regression including potential confounders. Levels of chlordecone plasma concentration in the third (OR=0.2; 95% confidence interval (CI): 0.1, 0.5) and fourth quartiles (OR=0.3; 95% CI: 0.2, 0.7) were associated with a statistically significant decrease in the risk of GH. A log10 increase in chlordecone concentration was significantly associated with lower risk of GH (OR=0.4; 95% CI: 0.2, 0.6). No significant associations were observed between the chlordecone exposure and the risk of PE or GDM. This study suggests an inverse association between chlordecone exposure during pregnancy and GH. Further studies are required to determine the underlying mechanism, or the potential unknown confounding factors, resulting in this association.</description>
<date>2014-07</date>
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