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<title lang=en>[Hydroxyurea-induced pneumonia].</title>
<creator>Girard, Anne</creator>
<creator>Ricordel, Charles</creator>
<creator>Poullot, Elsa</creator>
<creator>Claeyssen, Valérie</creator>
<creator>Decaux, Olivier</creator>
<creator>Desrues, Benoît</creator>
<creator>Delaval, Philippe</creator>
<creator>Jouneau, Stéphane</creator>
<contributor>Service de pneumologie ; Université de Rennes 1 (UR1) - CHU Rennes</contributor>
<contributor>Service d'hématologie clinique ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou</contributor>
<contributor>Service des urgences [Rennes] ; Hôpital Pontchaillou - Université de Rennes 1 (UR1) - CHU Rennes</contributor>
<contributor>Centre Hospitalier Universitaire [Rennes]</contributor>
<contributor>Contaminants Chimiques, immunité et Inflammation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; INSERM - École Nationale de la Santé Publique - Université de Rennes 1 (UR1) - Université des Antilles et de la Guyane (UAG) - Structure Fédérative de Recherche en Biologie-Santé de Rennes (Biosit) ; Université de Rennes 1 (UR1) - INSERM - CNRS - INSERM - CNRS - INSERM - École Nationale de la Santé Publique - Université de Rennes 1 (UR1) - Université des Antilles et de la Guyane (UAG) - Structure Fédérative de Recherche en Biologie-Santé de Rennes (Biosit) ; Université de Rennes 1 (UR1) - INSERM - CNRS - INSERM - CNRS - Service de pneumologie ; Université de Rennes 1 (UR1) - CHU Rennes - CHU Rennes</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; INSERM - École Nationale de la Santé Publique - Université de Rennes 1 (UR1) - Université des Antilles et de la Guyane (UAG) - Structure Fédérative de Recherche en Biologie-Santé de Rennes (Biosit) ; Université de Rennes 1 (UR1) - INSERM - CNRS - INSERM - CNRS</contributor>
<description>International audience</description>
<source>Revue des Maladies Respiratoires</source>
<publisher>Elsevier Masson</publisher>
<identifier>hal-01072996</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01072996</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01072996</source>
<source>Revue des Maladies Respiratoires, Elsevier Masson, 2014, 31 (5), pp.430-4. <10.1016/j.rmr.2013.09.001></source>
<identifier>DOI : 10.1016/j.rmr.2013.09.001</identifier>
<identifier>PUBMED : 24878159</identifier>
<language>fr</language>
<subject lang=en>Drug-induced pneumonitis</subject>
<subject lang=en>Fever</subject>
<subject lang=en>Hydroxyurea</subject>
<subject lang=en>Interstitial lung disease</subject>
<subject lang=en>Pneumopathie interstitielle</subject>
<subject lang=en>Pneumopathie médicamenteuse</subject>
<subject>[SDV.MHEP.PSR] Life Sciences/Human health and pathology/Pulmonology and respiratory tract</subject>
<type>Journal articles</type>
<description lang=en>INTRODUCTION: Hydroxyurea is an antimetabolite drug used in the treatment of myeloproliferative disorders. Common adverse effects include haematological, gastrointestinal cutaneous manifestations, and fever. Hydroxyurea-induced pneumonitis is unusual. CASE REPORT: A female patient was treated with hydroxyurea for polycythemia vera. She was admitted 20 days after commencing treatment with a high fever, productive cough, clear sputum and nausea. A chest CT-scan showed diffuse ground-glass opacities. Microbiological investigations were negative. The symptoms disappeared a few days after discontinuation of the drug and rechallenge led to a relapse of symptoms. CONCLUSION: Our case and 15 earlier cases of hydroxyurea-induced pneumonitis are reviewed. Two patterns of this disease may exist: an acute febrile form occurring within 1 month of introduction of hydroxyurea and a subacute form without fever. Even if uncommon, one should be aware of this complication of hydroxyurea.</description>
<date>2014-05</date>
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