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<publisher>HAL CCSD</publisher>
<title lang=en>Hemorheological alterations, decreased cerebral microvascular oxygenation and cerebral vasomotion compensation in sickle cell patients.</title>
<title lang=en>Hemorheological alterations, decreased cerebral microvascular oxygenation and cerebral vasomotion compensation in sickle cell patients. : Sickle cell disease and cerebral oxygenation</title>
<creator>Waltz, Xavier</creator>
<creator>Pichon, Aurélien</creator>
<creator>Mougenel, Danièle</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Lalanne-Mistrih, Marie-Laure</creator>
<creator>Sinnapah, Stéphane</creator>
<creator>Tarer, Vanessa</creator>
<creator>Tressières, Benoit</creator>
<creator>Lamarre, Yann</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Hue, Olivier</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Connes, Philippe</creator>
<contributor>Dynamique des Structures et Interactions des Macromolécules Biologiques- Pôle de La Réunion (DSIMB Réunion) ; Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB) ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de la Réunion (UR)</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Réponses Cellulaires et Fonctionnelles à l'Hypoxie (LRPH) ; Université Paris 13 (UP13) - Université Sorbonne Paris Cité (USPC) - UFR SMBH</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Service d'Orthopédie et de Traumatologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>This work was supported by local grants from the Academic Hospital of Pointe-à-Pitre (PHRC CHU de Pointe à Pitre). PhD funding of X.W. was supported by the association "Ensemble contre la drépanocytose" and by the regional council of Guadeloupe</contributor>
<description>International audience</description>
<source>ISSN: 0361-8609</source>
<source>EISSN: 1096-8652</source>
<source>American Journal of Hematology</source>
<publisher>Wiley</publisher>
<identifier>inserm-00838966</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00838966</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00838966/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00838966/file/2013_Waltz_American_Journalsur Hematology.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00838966</source>
<source>American Journal of Hematology, Wiley, 2012, 87 (12), pp.1070-3. 〈10.1002/ajh.23318〉</source>
<identifier>DOI : 10.1002/ajh.23318</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/ajh.23318</relation>
<identifier>PUBMED : 22911571</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22911571</relation>
<language>en</language>
<subject lang=en>Hemoglobinopathy</subject>
<subject lang=en>brain</subject>
<subject lang=en>microcirculation</subject>
<subject lang=en>oxygen</subject>
<subject lang=en>hypoxia</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Sickle cell anemia (SS) is characterized by a reduced cerebral microvascular oxygen saturation (cerebral TOI), which is not associated with hemoglobin concentration. Cerebral TOI has never been studied in sickle cell-hemoglobin C disease (SC). We focused on the relationships between hemorheological alterations and cerebral TOI in sickle cell patients with no cerebral vasculopathy and on the usefulness of TOI variability to assess the cerebral vasomotion activity. The blood rheological profile, the level of cerebral TOI (spatial resolved spectroscopy) and the cerebral TOI variability, which reflects vasomotion activity, were compared between 20 healthy subjects (AA), 21 SC patients, and 21 SS patients. Cerebral TOI exhibited the following order: AA > SC > SS. The low cerebral TOI in SS patients was related to red blood cell aggregation and deformability properties. The cerebral TOI variability of SS and SC patients was increased above healthy values and vasomotion activity was negatively associated with the reduced cerebral TOI in SS patients. We demonstrated that (1) blood rheology could be involved in the reduced cerebral TOI in SS patients but not in SC patients; (2) vasomotion activity is increased in SS and SC patients to compensate for the reduced cerebral TOI.</description>
<date>2012-12</date>
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