Manioc : Portail | resultats 21 - 40 pour la recherche: V. Girard

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case-control study comprised 410 patients who had surgery for a pituitary tumour with long-term follow-up. Using pituitary magnetic resonance imaging for diagnosis of cavernous or sphenoid sinus invasion, immunocytochemistry, markers of the cell cycle (Ki-67, mitoses) and p53, tumours were classified according to size (micro, macro and giant), type (PRL, GH, FSH/LH, ACTH and TSH) and grade (grade 1a: non-invasive, 1b: non-invasive and proliferative, 2a: invasive, 2b: invasive and proliferative, and 3: metastatic). The association between patient status at 8-year follow-up and age, sex, and classification was evaluated by two multivariate analyses assessing disease- or recurrence/progression-free status. At 8 years after surgery, 195 patients were disease-free (controls) and 215 patients were not (cases). In 125 of the cases the tumours had recurred or progressed. Analyses of disease-free and recurrence/progression-free status revealed the significant prognostic value (p < 0.001; p < 0.05) of age, tumour type, and grade across all tumour types and for each tumour type. Invasive and proliferative tumours (grade 2b) had a poor prognosis with an increased probability of tumour persistence or progression of 25- or 12-fold, respectively, as compared to non-invasive tumours (grade 1a). This new, easy to use clinicopathological classification of pituitary endocrine tumours has demonstrated its prognostic worth by strongly predicting the probability of post-operative complete remission or tumour progression and so could help clinicians choose the best post-operative therapy.
ISSN: 0001-6322

hal-00875723
https://hal.archives-ouvertes.fr/hal-00875723
DOI : 10.1007/s00401-013-1084-y
PUBMED : 23400299

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L'illustration. N°3358
Auteur(s) : Galmot, Jean (1879-1928)
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Annuaire de la Guadeloupe et dépendances pour l'année 1904
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Bulletin officiel de la Guyane française
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Géographie complète et universelle : illustrée de 50 gravures, 8 cartes, 5 planches et du portrait de l'auteur. Tome quatrième
Auteur(s) : Malte-Brun, Conrad (1775-1826)
Auteurs secondaires : Malte-Brun, Victor-Adolphe (1816-1889)
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Histoire des drogues espiceries, et de certains medicamens simples, qui naissent és Indes tant orientales, que occidentales, divisée en deux parties. La premiere composée de trois livres: les deux premiers de M. Garcie du Jardin, & le troisiesme de M. Christophle de La Coste. La seconde composee de deux livres de M. Nicolas Monard, traittant de ce qui nous est apporté des Indes occidentales, autrement appellées les terres neuves. Le tout fidelement translaté en nostre vulgaire françois sur la traduction latine de Clusius : par Anthoine Colin apoticaire juré de la ville de Lyon: & par luy augmenté de plusieurs figures.
Auteur(s) : Orta, Garcia de (1499-1568) Acosta, Christoval (1515?-1592?) Monardes, Nicolás (1512?-1588)
Auteurs secondaires : L'Écluse, Charles de (1526-1609) Colin, Antoine (156.-16..)
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