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<title lang=en>A micro-QuEChERS method coupled to GC-MS for the quantification of pesticides in specific maternal and fetal tissues.</title>
<creator>Brandhonneur, Nolwenn</creator>
<creator>De Sousa Mendes, Maïlys</creator>
<creator>Lepvrier, Eléonore</creator>
<creator>Flejou Esseiva, E</creator>
<creator>Chevanne, François</creator>
<creator>Le Corre, Pascal</creator>
<contributor>Laboratoire de Pharmacie Galenique, Biopharmacie et Pharmacie Clinique ; Université de Rennes 1 (UR1)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Service de pharmacie ; CHU Pontchaillou [Rennes]</contributor>
<contributor>This work was partially supported by the French Ministry for the Environment and Sustainable Development (Antiopes, project EXPIOMARK, INERIS).</contributor>
<description>International audience</description>
<source>ISSN: 0731-7085</source>
<source>Journal of Pharmaceutical and Biomedical Analysis</source>
<publisher>Elsevier</publisher>
<identifier>hal-01122837</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122837</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122837</source>
<source>Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2015, 104, pp.90-6. 〈10.1016/j.jpba.2014.10.035〉</source>
<identifier>PUBMED : 25497890</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25497890</relation>
<identifier>DOI : 10.1016/j.jpba.2014.10.035</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2014.10.035</relation>
<language>en</language>
<subject lang=en>pesticides</subject>
<subject lang=en>metabolites</subject>
<subject lang=en>micro-QuEChERS</subject>
<subject lang=en>fetal tissue distribution</subject>
<subject>[SDV.BDD] Life Sciences [q-bio]/Development Biology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The aim of this study was to establish a new QuEChERS (quick, easy, cheap, effective, rugged and safe) method coupled to gas chromatography-mass spectrometry (GC-MS) detection for the evaluation of the pesticide biodistribution in specific maternal and fetal tissues. This method was validated for the quantification of pesticides such as chlorotriazines (atrazine, simazine and propazine), their chlorinated metabolites (DIA, DEA and DACT). This new QuEChERS method was developed to facilitate extraction from small tissues such as fetal tissues (mean value: 200mg). The limits of detection, quantification, recovery, precision and accuracy were evaluated for different tissues (liver and brain) and blood. LOD and LOQ ranged between 0.34 and 3.27 ng/g and 1.04 to 9.91 ng/g, respectively. Recovery exceeded 80% for all pesticides, except DACT, with an associated RSD<15%. Precision and accuracy satisfied the criteria usually applied in the validation of bioanalytical methods. The results obtained indicate that this technique is suitable for use in studies of the biodistribution of pesticides in fetal tissues and can be used to evaluate the risk of exposure to pesticides during gestation.</description>
<date>2015-01-31</date>
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