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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.</title>
<creator>Lamarre, Yann</creator>
<creator>Lalanne-Mistrih, Marie-Laure</creator>
<creator>Romana, Marc</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Mougenel, Daniele</creator>
<creator>Waltz, Xavier</creator>
<creator>Tressières, Benoît</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Tarer, Vanessa</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Connes, Philippe</creator>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Laboratoire d'excellence GR-Ex " The red cell: from genesis to death " (LABEX GR-Ex) ; PRES Sorbonne Paris Cité</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Unité Transversale de la Drépanocytose ; Hôpital Ricou - CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>inserm-00838991</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00838991</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00838991/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00838991/file/Lamarre_et_al._2013_PloS_ONE_.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00838991</source>
<source>PLoS ONE, Public Library of Science, 2013, 8 (6), pp.e66004. 〈10.1371/journal.pone.0066004〉</source>
<identifier>DOI : 10.1371/journal.pone.0066004</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0066004</relation>
<identifier>PUBMED : 23785465</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23785465</relation>
<language>en</language>
<subject lang=en>Sickle cell anemia</subject>
<subject lang=en>relative hypertension</subject>
<subject lang=en>blood viscosity</subject>
<subject lang=en>vaso-occlusive crisis</subject>
<subject lang=en>atherogenic index of plasma</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Patients with sickle cell anemia (SCA) have usually lower diastolic, systolic and mean blood pressure (BP) than the general population. However, BP values ≥120/70 mmHg considerably increase the risk for acute and chronic complications in SCA. The aim of this study was to identify biological factors associated with relative hypertension in adults with SCA. We compared the hematological, lipid and hemolytic profiles, as well as blood viscosity, between SCA patients with normal BP (<120/70 mmHg, n = 54) and those with relative hypertension (BP≥120/70 mmHg, n = 43). Our results demonstrated that male gender (OR: 3.49; 95%CI 1.20 to 10.16, p<0.05), triglycerides (OR: 9.19; 95% CI 2.29 to 36.95, p<0.01), blood viscosity (OR: 1.35; 95% CI 1.01 to 1.81, p<0.05) and body mass index (OR: 1.37; 95% CI 1.14 to 1.64, p<0.01) were independent risks factors for relative hypertension in SCA. No association was found between the BP status and the positive history of painful vaso-occlusive crisis or acute chest syndrome. An association between triglycerides level and the occurrence of these two major acute complications was detected. Our study suggests that male gender, increased triglycerides level, BMI and blood viscosity could increase the risk for developing relative hypertension in SCA. In addition, our results support a role of moderately elevated triglycerides in the pathophysiology of vaso-occlusive events.</description>
<date>2013</date>
</dc>
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