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<identifier>oai:HAL:inserm-00863407v1</identifier>
<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Metabolomics tools for describing complex pesticide exposure in pregnant women in brittany (france).</title>
<creator>Bonvallot, Nathalie</creator>
<creator>Tremblay-Franco, Marie</creator>
<creator>Chevrier, Cécile</creator>
<creator>Canlet, Cécile</creator>
<creator>Warembourg, Charline</creator>
<creator>Cravedi, Jean-Pierre</creator>
<creator>Cordier, Sylvaine</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>xénobiotiques ; ToxAlim (ToxAlim) ; Institut National Polytechnique [Toulouse] (INP) - Institut National de la Recherche Agronomique (INRA) - Université Paul Sabatier - Toulouse 3 (UPS) - Ecole Nationale Vétérinaire de Toulouse - Institut National Polytechnique [Toulouse] (INP) - Institut National de la Recherche Agronomique (INRA) - Université Paul Sabatier - Toulouse 3 (UPS) - Ecole Nationale Vétérinaire de Toulouse</contributor>
<contributor>This work was supported by grants from the EHESP-School of Public Health (Young researchers, www.ehesp.fr) and the French Ministry for Environment and sustainable development (Antiopes, INERIS)</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>inserm-00863407</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00863407</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00863407/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00863407/file/journal.pone.0064433.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00863407</source>
<source>PLoS ONE, Public Library of Science, 2013, 8 (5), pp.e64433. 〈10.1371/journal.pone.0064433〉</source>
<identifier>PUBMED : 23704985</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23704985</relation>
<identifier>DOI : 10.1371/journal.pone.0064433</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0064433</relation>
<language>en</language>
<subject>[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: The use of pesticides and the related environmental contaminations can lead to human exposure to various molecules. In early-life, such exposures could be responsible for adverse developmental effects. However, human health risks associated with exposure to complex mixtures are currently under-explored. OBJECTIVE: THIS PROJECT AIMS AT ANSWERING THE FOLLOWING QUESTIONS: What is the influence of exposures to multiple pesticides on the metabolome? What mechanistic pathways could be involved in the metabolic changes observed? METHODS: Based on the PELAGIE cohort (Brittany, France), 83 pregnant women who provided a urine sample in early pregnancy, were classified in 3 groups according to the surface of land dedicated to agricultural cereal activities in their town of residence. Nuclear magnetic resonance-based metabolomics analyses were performed on urine samples. Partial Least Squares Regression-Discriminant Analysis (PLS-DA) and polytomous regressions were used to separate the urinary metabolic profiles from the 3 exposure groups after adjusting for potential confounders. RESULTS: The 3 groups of exposure were correctly separated with a PLS-DA model after implementing an orthogonal signal correction with pareto standardizations (R2 = 90.7% and Q2 = 0.53). After adjusting for maternal age, parity, body mass index and smoking habits, the most statistically significant changes were observed for glycine, threonine, lactate and glycerophosphocholine (upward trend), and for citrate (downward trend). CONCLUSION: This work suggests that an exposure to complex pesticide mixtures induces modifications of metabolic fingerprints. It can be hypothesized from identified discriminating metabolites that the pesticide mixtures could increase oxidative stress and disturb energy metabolism.</description>
<date>2013</date>
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