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<identifier>oai:HAL:hal-01619303v1</identifier>
<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome</title>
<creator>Gemmel, Mary</creator>
<creator>Bögi, Eszter</creator>
<creator>Ragan, Christina</creator>
<creator>Hazlett, Mariah</creator>
<creator>Dubovicky, Michal</creator>
<creator>Van Den Hove, Daniel, </creator>
<creator>Oberlander, Tim, </creator>
<creator>Charlier, Thierry, </creator>
<creator>Pawluski, Jodi, </creator>
<contributor>Department of Biological Sciences [Athens] ; Ohio University</contributor>
<contributor>Institute of Experimental Pharmacology and Toxicology ; Slovak Academy of Science [Bratislava] (SAS)</contributor>
<contributor>Department of Psychology ; Colgate University</contributor>
<contributor>Maastricht University [Maastricht]</contributor>
<contributor>University of Würzburg</contributor>
<contributor>University of British Columbia (UBC)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>JLP is funded by a Brain & Behavior Foundation NARSAD Young Investigator Grant. TDC is funded by the Region Bretagne (SAD) and Rennes Metropole. MD is funded by the VEGA project 2/0168/15 (Slovak Grant Agency). </contributor>
<description>International audience</description>
<source>ISSN: 0149-7634</source>
<source>Neuroscience and Biobehavioral Reviews</source>
<publisher>Elsevier</publisher>
<identifier>hal-01619303</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01619303</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01619303/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01619303/file/Perinatal%20selective%20serotonin%20reuptake%20inhibitor%20medication_revised.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01619303</source>
<source>Neuroscience and Biobehavioral Reviews, Elsevier, 2017, in press, 〈10.1016/j.neubiorev.2017.04.023〉</source>
<identifier>DOI : 10.1016/j.neubiorev.2017.04.023</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neubiorev.2017.04.023</relation>
<identifier>PUBMED : 28472631</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28472631</relation>
<language>en</language>
<subject lang=en>Perinatal depression</subject>
<subject lang=en>Offspring</subject>
<subject lang=en>Development</subject>
<subject lang=en>Play behavior</subject>
<subject lang=en>Social interaction</subject>
<subject lang=en>Reproductive behavior</subject>
<subject lang=en>Antidepressant</subject>
<subject lang=en>Maternal anxiety</subject>
<subject lang=en>Serotonin</subject>
<subject lang=en>Maternal stress</subject>
<subject lang=en>Sex differences</subject>
<subject lang=en>Maternal care</subject>
<subject lang=en>Stress</subject>
<subject lang=en>Pregnancy</subject>
<subject lang=en>SSRI</subject>
<subject>[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</subject>
<subject>[SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis</subject>
<subject>[SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Recent research has linked early life exposure to selective serotonin reuptake inhibitor medications (SSRIs) to modifications of social behaviors in children. Serotonin is a key regulator of neurodevelopment, social behaviors and mental health, and with the growing use of SSRIs to treat maternal affective disorders during the perinatal period, questions have been raised about the benefits and risks of perinatal SSRI exposure on the developing child. This review will highlight how perinatal SSRIs affect maternal care and neurodevelopmental outcomes related to social affiliative behaviors in offspring; such as play behaviors, social interactions, reproductive behaviors, and maternal care of the next generation. We will also review how early life exposure to SSRIs can alter related neurobiology, and the epigenome. Both clinical research and findings from animal models will be discussed. Understanding the impact of perinatal SSRIs on neurobehavioral outcomes will improve the health and well-being of subsequent generations.</description>
<date>2017</date>
</dc>
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