untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-17T12:07:46Z</responseDate>
<request identifier=oai:HAL:hal-01544760v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-01544760v1</identifier>
<datestamp>2018-01-12</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:EVOLUTION_PARIS_SEINE</setSpec>
<setSpec>collection:UPMC</setSpec>
<setSpec>collection:EVOL_PARIS_SEINE-EGE</setSpec>
<setSpec>collection:CNRS</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:UNICE</setSpec>
<setSpec>collection:SAE</setSpec>
<setSpec>collection:GIP-BE</setSpec>
<setSpec>collection:UPMC_POLE_4</setSpec>
<setSpec>collection:IBPS</setSpec>
<setSpec>collection:UCA-TEST</setSpec>
<setSpec>collection:UNIV-COTEDAZUR</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Properties of selected mutations and genotypic landscapes under Fisher's geometric model</title>
<creator>Blanquart, Francois</creator>
<creator>Achaz, Guillaume</creator>
<creator>Bataillon, Thomas</creator>
<creator>Tenaillon, Olivier</creator>
<contributor>Evolution des Génomes Eucaryotes (EGE) ; Systématique, adaptation, évolution (SAE) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS) - Evolution Paris Seine ; Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Centre National de la Recherche Scientifique (CNRS) - Université des Antilles et de la Guyane (UAG) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Danish Research Council (FFF-FNU)</contributor>
<contributor> European Research Council under the European Union [311341, 310944]</contributor>
<contributor> French ``Ministere de la Recherche''</contributor>
<contributor> Bettencourt Foundation</contributor>
<contributor> Agence Nationale de la Recherche [ANR-12-JSV7-0007]</contributor>
<description>International audience</description>
<source>ISSN: 0014-3820</source>
<source>Evolution</source>
<publisher>Wiley</publisher>
<identifier>hal-01544760</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01544760</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01544760</source>
<source>Evolution, Wiley, 2014, 68 (12), pp.3537-3554. 〈10.1111/evo.12545〉</source>
<identifier>DOI : 10.1111/evo.12545</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/evo.12545</relation>
<language>en</language>
<subject lang=en>Adaptation</subject>
<subject lang=en> epistasis</subject>
<subject lang=en> experimental evolution</subject>
<subject lang=en> NK model</subject>
<subject lang=en> Rough Mount Fuji</subject>
<subject lang=en> selection</subject>
<subject>[SDV.BID] Life Sciences [q-bio]/Biodiversity</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The fitness landscapethe mapping between genotypes and fitnessdetermines properties of the process of adaptation. Several small genotypic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness of all combinations of these mutations. Here, we generate several testable predictions for the properties of these small genotypic landscapes under Fisher's geometric model of adaptation. When the ancestral strain is far from the fitness optimum, we analytically compute the fitness effect of selected mutations and their epistatic interactions. Epistasis may be negative or positive on average depending on the distance of the ancestral genotype to the optimum and whether mutations were independently selected, or coselected in an adaptive walk. Simulations show that genotypic landscapes built from Fisher's model are very close to an additive landscape when the ancestral strain is far from the optimum. However, when it is close to the optimum, a large diversity of landscape with substantial roughness and sign epistasis emerged. Strikingly, small genotypic landscapes built from several replicate adaptive walks on the same underlying landscape were highly variable, suggesting that several realizations of small genotypic landscapes are needed to gain information about the underlying architecture of the fitness landscape.</description>
<date>2014-12</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>