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<datestamp>2017-12-21</datestamp>
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<title lang=en>Rapid assessment of estrogenic compounds by CXCL-test illustrated by the screening of the UV-filter derivative benzophenones.</title>
<creator>Habauzit, Denis</creator>
<creator>Martin, Catherine</creator>
<creator>Kerdivel, Gwenneg</creator>
<creator>Pakdel, Farzad</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>This work was supported by funds from the French Ministry of Ecology, Energy and Sustainable Development (PNRPE). We also thank CNRS, INSERM and the University of Rennes 1 for supporting our research.</contributor>
<description>International audience</description>
<source>ISSN: 0045-6535</source>
<source>Chemosphere</source>
<publisher>Elsevier</publisher>
<identifier>hal-01477205</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477205</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477205/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477205/file/Rapid%20assessment%20of%20estrogenic%20compounds_accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477205</source>
<source>Chemosphere, Elsevier, 2017, 173, pp.253-260. 〈10.1016/j.chemosphere.2017.01.037〉</source>
<identifier>DOI : 10.1016/j.chemosphere.2017.01.037</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.chemosphere.2017.01.037</relation>
<identifier>PUBMED : 28110015</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28110015</relation>
<language>en</language>
<subject lang=en>Estrogens</subject>
<subject lang=en>Detection</subject>
<subject lang=en>CXCL-test</subject>
<subject lang=en>Endocrine disrupting chemicals</subject>
<subject lang=en>Benzophenone</subject>
<subject lang=en>Xeno-estrogens</subject>
<subject>[SDV.EE] Life Sciences [q-bio]/Ecology, environment</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>CXCL-test is a method that uses the estrogen-dependent secretion of the natural endogenous chemokine CXCL12 to evaluate the estrogenic activity of molecules. CXCL12 chemokine is involved in the estrogen dependent proliferation of breast cancer cells. Its measure is an indicator of cell proliferation and is used as an alternative test to classical proliferation test. Here we aimed to optimize this test, first to increase the number of tested molecules in a single assay and then to decrease the number of intermediate steps. The optimized CXCL-test was finally used for the evaluation of the estrogenic potency of emerging chemical pollutants: the UV filter benzophenones (BPs). The effect of BPs on CXCL12 secretion was also validated by real time quantitative RT-PCR. The optimized CXCL-test allowed a fast and direct assessment of estrogenic potency of molecules. The estrogenic activities of benzophenones were characterized and divided in two groups. The first one contains weak estrogenic compounds (BP, BP1, BP2, BP3, 234BP and 2344′BP). The second one contains medium estrogenic compounds (4BP, 44′BP, BP8, THB).</description>
<date>2017-04-01</date>
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