untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:26:48Z</responseDate>
<request identifier=oai:HAL:hal-01211587v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-01211587v1</identifier>
<datestamp>2018-01-11</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:UNIV-AMU</setSpec>
<setSpec>collection:CNRS</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:IRD</setSpec>
<setSpec>collection:GIP-BE</setSpec>
<setSpec>collection:INSERM</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Cytokine Regulation of Periportal Fibrosis in Humans Infected with Schistosoma mansoni: IFN-γ is Associated with Protection Against Fibrosis and TNF-α with Aggravation of Disease</title>
<creator>Henri, Sandrine</creator>
<creator>Chevillard, Christophe</creator>
<creator>Mergani, Adil</creator>
<creator>Paris, Patricia</creator>
<creator>Gaudart, Jean</creator>
<creator>Camilla, Christophe</creator>
<creator>Dessein, Hélia</creator>
<creator>Montero, Felix</creator>
<creator>El Wali, Nasureldin</creator>
<creator>Saeed, O. K.</creator>
<creator>Magzoub, Mubarak</creator>
<creator>Dessein, Alain</creator>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Génétique et immunologie des maladies parasitaires (GIMP) ; Aix Marseille Université (AMU) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>St. Louis University (SLU) ; Washington University in St Louis</contributor>
<contributor>Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM) ; Institut de Recherche pour le Développement (IRD) - Aix Marseille Université (AMU) - ORS PACA - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Aix Marseille Université (AMU)</contributor>
<contributor>Cavanilles Institute of Biodiversity and Evolutionary Biology ; University of Valencia</contributor>
<contributor>University of Gezira</contributor>
<description>International audience</description>
<source>ISSN: 0022-1767</source>
<source>EISSN: 1550-6606</source>
<source>Journal of Immunology</source>
<publisher>Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists</publisher>
<identifier>hal-01211587</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01211587</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01211587/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01211587/file/929.full.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01211587</source>
<source>Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2002, 169 (2), pp.929-936. 〈http://www.jimmunol.org/content/169/2/929.full.pdf+html〉. 〈10.4049/jimmunol.169.2.929〉</source>
<identifier>DOI : 10.4049/jimmunol.169.2.929</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.4049/jimmunol.169.2.929</relation>
<source>http://www.jimmunol.org/content/169/2/929.full.pdf+html</source>
<language>en</language>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<subject>[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases</subject>
<subject>[SDV.IMM] Life Sciences [q-bio]/Immunology</subject>
<subject>[SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Hepatic periportal fibrosis, which affects 5–10% of subjects infected by Schistosoma mansoni, is caused by the T cell-dependent granuloma that develop around schistosome eggs. Experimental models of infection have shown that granuloma and fibrosis are tightly regulated by cytokines. However, it is unknown why advanced periportal fibrosis occurs only in certain subjects. The goal of the present study was to evaluate the cytokine response of S. mansoni-infected subjects with advanced liver disease in an attempt to relate susceptibility to periportal fibrosis with an abnormal production of cytokines that regulate granuloma and fibrosis. Fibrosis was evaluated by ultrasound on 795 inhabitants of a Sudanese village in which S. mansoni is endemic: advanced periportal fibrosis was observed in 12% of the population; 35% of the affected subjects exhibited signs of portal hypertension. Age (odds ratio (OR), 11.5), gender (OR, 4.2), and infection levels (OR, 2.2) were significantly (p < 0.01) associated with hepatic fibrosis. Cytokines produced by egg-stimulated blood mononuclear cells from 99 subjects were measured (75 with no or mild fibrosis; 24 subjects with advanced fibrosis). Multivariate analysis of cytokine levels showed that high IFN-γ levels were associated with a marked reduction of the risk of fibrosis (p = OR, 0.1); in contrast, high TNF-α levels were associated with an increased risk (p = 0.05; OR, 4.6) of periportal fibrosis. Moreover, infection levels were negatively associated with IFN-γ production. These results with observations in experimental models strongly suggest that IFN-γ plays a key role in the protection of S. mansoni-infected patients against periportal fibrosis, whereas TNF-α may aggravate the disease.</description>
<rights>http://creativecommons.org/licenses/by-nc-nd/</rights>
<date>2002</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>