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<publisher>HAL CCSD</publisher>
<title lang=en>Chlordecone exposure and risk of prostate cancer.</title>
<creator>Multigner, Luc</creator>
<creator>Ndong, Jean-Rodrigue</creator>
<creator>Giusti, Arnaud</creator>
<creator>Romana, Marc</creator>
<creator>Delacroix-Maillard, Helene</creator>
<creator>Cordier, Sylvaine</creator>
<creator>Jégou, Bernard</creator>
<creator>Thome, Jean-Pierre</creator>
<creator>Blanchet, Pascal</creator>
<contributor>Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM) ; Université de Rennes 1 (UR1) - IFR140 - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service d'urologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre</contributor>
<contributor>Laboratory of Animal Ecology and Ecotoxicology ; Université de Liège</contributor>
<contributor>Pharmacogénétique et abords thérapeutiques des maladies héréditaires ; Université des Antilles et de la Guyane (UAG) - Université Paris Diderot - Paris 7 (UPD7) - IFR2 - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Centre d'Examens de Santé Sainte Geneviève ; Centre d'Examens de Santé Sainte Geneviève</contributor>
<description>International audience</description>
<source>ISSN: 0732-183X</source>
<source>EISSN: 1527-7755</source>
<source>Journal of Clinical Oncology</source>
<publisher>American Society of Clinical Oncology</publisher>
<identifier>inserm-00518099</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00518099</identifier>
<source>http://www.hal.inserm.fr/inserm-00518099</source>
<source>Journal of Clinical Oncology, American Society of Clinical Oncology, 2010, 28 (21), pp.3457-62. 〈10.1200/JCO.2009.27.2153〉</source>
<identifier>DOI : 10.1200/JCO.2009.27.2153</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1200/JCO.2009.27.2153</relation>
<identifier>PUBMED : 20566993</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/20566993</relation>
<language>en</language>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<subject>[SDV.TOX] Life Sciences [q-bio]/Toxicology</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>PURPOSE: Determining whether environmental estrogens are associated with the risk of prostate cancer may have important implications for our general understanding of this disease. The estrogenic insecticide chlordecone was used extensively in the French West Indies, contaminating the population for more than 30 years. We analyzed the relationship between exposure to chlordecone and the risk of prostate cancer. PATIENTS AND METHODS: We investigated 623 men with prostate cancer and 671 controls. Exposure was analyzed according to case-control status, using either current plasma concentration or a cumulative exposure index based on years of exposure. We genotyped two single-nucleotide polymorphisms (rs3829125 and rs17134592) in the gene encoding chlordecone reductase. RESULTS: We found a significant increase in the risk of prostate cancer with increasing plasma chlordecone concentration (odds ratio [OR], 1.77; 95% CI, 1.21 to 2.58 for the highest tertile of values above the limit of detection [LD]; P trend = .002) and for cumulative exposure index (OR, 1.73; 95% CI, 1.04 to 2.88 for the highest quartile; P trend = .004). Stronger associations were observed among those with a positive family history of prostate cancer and among those who had lived in a Western country. The rs3829125 and rs17134592 allele variants were in complete linkage disequilibrium and were found at low frequency (0.04). Among subjects with plasma chlordecone concentrations above the LD, carriers of the allele variants had a higher risk of prostate cancer (OR, 5.23; 95% CI, 0.82 to 33.32). CONCLUSION: These findings support the hypothesis that exposure to environmental estrogens increases the risk of prostate cancer.</description>
<date>2010-07-20</date>
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