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<datestamp>2018-01-11</datestamp>
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<title lang=en>Cytosine modifications modulate the chromatin architecture of transcriptional enhancers</title>
<creator>Mahé, Elise A.</creator>
<creator>Madigou, Thierry</creator>
<creator>Sérandour, Aurélien A.</creator>
<creator>Bizot, Maud</creator>
<creator>Avner, Stéphane</creator>
<creator>Chalmel, Frédéric</creator>
<creator>Palierne, Gaëlle</creator>
<creator>Métivier, Raphaël</creator>
<creator>Salbert, Gilles</creator>
<contributor>Institut de Génétique et Développement de Rennes (IGDR) ; Université de Rennes 1 (UR1) - Centre National de la Recherche Scientifique (CNRS) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>European Molecular Biology Laboratory [Heidelberg] (EMBL)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>This work was supported by the CNRS, the University of Rennes I, and the Association de la Recherche contre le Cancer. </contributor>
<description>“Human and Environmental Genomics” platform (Rennes) for Illumina sequencing / Proteomics Core Facility of the Cambridge Institute (Cancer Research UK)</description>
<description>International audience</description>
<source>ISSN: 1088-9051</source>
<source>EISSN: 1549-5469</source>
<source>Genome Research</source>
<publisher>Cold Spring Harbor Laboratory Press</publisher>
<identifier>hal-01533248</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01533248</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01533248/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01533248/file/Genome%20Res.-2017-Mah%C3%A9-947-58.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01533248</source>
<source>Genome Research, Cold Spring Harbor Laboratory Press, 2017, 27 (6), pp.947-958. 〈10.1101/gr.211466.116〉</source>
<identifier>DOI : 10.1101/gr.211466.116</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1101/gr.211466.116</relation>
<identifier>PUBMED : 28396520</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28396520</relation>
<language>en</language>
<subject>[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Epigenetic mechanisms are believed to play key roles in the establishment of cell-specific transcription programs. Accordingly, the modified bases 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have been observed in DNA of genomic regulatory regions such as enhancers, and oxidation of 5mC into 5hmC by Ten-eleven translocation (TET) proteins correlates with enhancer activation. However, the functional relationship between cytosine modifications and the chromatin architecture of enhancers remains elusive. To gain insights into their function, 5mC and 5hmC levels were perturbed by inhibiting DNA methyltransferases and TETs during differentiation of mouse embryonal carcinoma cells into neural progenitors, and chromatin characteristics of enhancers bound by the pioneer transcription factors FOXA1, MEIS1, and PBX1 were interrogated. In a large fraction of the tested enhancers, inhibition of DNA methylation was associated with a significant increase in monomethylation of H3K4, a characteristic mark of enhancer priming. In addition, at some specific enhancers, 5mC oxidation by TETs facilitated chromatin opening, a process that may stabilize MEIS1 binding to these genomic regions.</description>
<rights>http://creativecommons.org/licenses/by-nc/</rights>
<date>2017</date>
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