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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism</title>
<creator>Hardonniere, Kévin</creator>
<creator>Huc, Laurence, </creator>
<creator>Sergent, Odile</creator>
<creator>Holme, Jørn, </creator>
<creator>Lagadic-Gossmann, Dominique</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>ToxAlim (ToxAlim) ; Institut National Polytechnique [Toulouse] (INP) - Institut National de la Recherche Agronomique (INRA) - Université Paul Sabatier - Toulouse 3 (UPS) - Ecole Nationale Vétérinaire de Toulouse</contributor>
<contributor>Division of Environmental Medicine ; Norwegian Institute of Public Health</contributor>
<contributor>This work was financially supported by the French Ministry of Research, Région Bretagne, the Ligue contre le Cancer, and the French National Agency for Research (ANR; STEATOX project: ANR-13-CESA-0009).</contributor>
<description>International audience</description>
<source>ISSN: 1044-579X</source>
<source>EISSN: 1096-3650</source>
<source>Seminars in Cancer Biology</source>
<publisher>Elsevier</publisher>
<identifier>hal-01531077</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01531077</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01531077/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01531077/file/Hardonniere%20et%20al.%20-%20Environmental%20carcinogenesis%20and%20pH%20homeostasis%20n.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01531077</source>
<source>Seminars in Cancer Biology, Elsevier, 2017, 43, pp.49-65. 〈10.1016/j.semcancer.2017.01.001〉</source>
<identifier>DOI : 10.1016/j.semcancer.2017.01.001</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.semcancer.2017.01.001</relation>
<identifier>PUBMED : 28088583</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28088583</relation>
<language>en</language>
<subject lang=en>pH and carcinogenesis</subject>
<subject lang=en>Benzo[a]pyrene</subject>
<subject lang=en>Na+/H+ exchanger</subject>
<subject lang=en>Apoptosis</subject>
<subject lang=en>Warburg effect</subject>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<subject>[SDV.TOX] Life Sciences [q-bio]/Toxicology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>According to the World Health Organization, around 20% of all cancers would be due to environmental factors. Among these factors, several chemicals are indeed well recognized carcinogens. The widespread contaminant benzo[a]pyrene (B[a]P), an often used model carcinogen of the polycyclic aromatic hydrocarbons' family, has been suggested to target most, if not all, cancer hallmarks described by Hanahan and Weinberg. It is classified as a group I carcinogen by the International Agency for Research on Cancer; however, the precise intracellular mechanisms underlying its carcinogenic properties remain yet to be thoroughly defined. Recently, the pH homeostasis, a well known regulator of carcinogenic processes, was suggested to be a key actor in both cell death and Warburg-like metabolic reprogramming induced upon B[a]P exposure. The present review will highlight those data with the aim of favoring research on the role of H + dynamics in environmental carcinogenesis.</description>
<date>2017</date>
<contributor>ANR-13-CESA-0009, STEATOX, Impact des agents chimiques environnementaux sur les mécanismes de progression pathologique de la stéatose hépatique(2013)</contributor>
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