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<title lang=en>Expression screening of cancer/testis genes in prostate cancer identifies nr6a1 as a novel marker of disease progression and aggressiveness.</title>
<creator>Mathieu, Romain</creator>
<creator>Evrard, Bertrand</creator>
<creator>Fromont, Gaëlle</creator>
<creator>Rioux-Leclercq, Nathalie</creator>
<creator>Godet, Julie</creator>
<creator>Cathelineau, Xavier</creator>
<creator>Guillé, François</creator>
<creator>Primig, Michael</creator>
<creator>Chalmel, Frédéric</creator>
<contributor>Transcriptional networks in gametogenesis and cancer ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Cellules souches leucémiques et thérapeuthiques ; Université de Poitiers - CHU de Poitiers</contributor>
<contributor>Service d'anatomie et cytologie pathologiques [Rennes] ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<contributor>Département d'Anatomocytopathologie ; CHU de Poitiers</contributor>
<contributor>CRLCC Eugène Marquis (CRLCC)</contributor>
<contributor>International Genomic Consortium (IGC) ; Expression Project for Oncology (expO) ; bourse ARTP à R.M. ; bourse ARC no. 7985 et bourse Inserm Avenir R07216NS à M.P.</contributor>
<description>International audience</description>
<source>ISSN: 0270-4137</source>
<source>EISSN: 1097-0045</source>
<source>Prostate</source>
<publisher>Wiley</publisher>
<identifier>inserm-00821963</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00821963</identifier>
<source>http://www.hal.inserm.fr/inserm-00821963</source>
<source>Prostate, Wiley, 2013, 73 (10), pp.1103-1114. 〈10.1002/pros.22659〉</source>
<identifier>DOI : 10.1002/pros.22659</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/pros.22659</relation>
<identifier>PUBMED : 23532770</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23532770</relation>
<language>en</language>
<subject lang=en>Cancer/Testis genes</subject>
<subject lang=en>castration-resistant prostate cancer</subject>
<subject lang=en>biomarker</subject>
<subject lang=en>NR6A1</subject>
<subject lang=en>nuclear receptor</subject>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Cancer/Testis (CT) genes are expressed in male gonads, repressed in most healthy somatic tissues and de-repressed in various somatic malignancies including prostate cancers (PCa). Because of their specific expression signature and their associations with tumor aggressiveness and poor outcomes, CT genes are considered to be useful biomarkers and they are also targets for the development of new anti-cancer immunotherapies. The aim of this study was to identify novel CT genes associated with hormone-sensitive prostate cancer (HSPC), and castration-resistant prostate cancer (CRPC). METHODS: To identify novel CT genes we screened genes for which transcripts were detected by RNA profiling specifically in normal testis and in either HSPC or CRPC as compared to normal prostate and 44 other healthy tissues using GeneChips. The expression and clinicopathological significance of a promising candidate-NR6A1-was examined in HSPC, CRPC, and metastatic site samples using tissue microarrays. RESULTS: We report the identification of 98 genes detected in CRPC, HSPC and testicular samples but not in the normal controls. Among them, cellular levels of NR6A1 were found to be higher in HSPC compared to normal prostate and further increased in metastatic lesions and CRPC. Furthermore, increased NR6A1 immunoreactivity was significantly associated with a high Gleason score, advanced pT stage and cancer cell proliferation. CONCLUSIONS: Our results show that cellular levels of NR6A1 are correlated with disease progression in PCa. We suggest that this essential orphan nuclear receptor is a potential therapeutic target as well as a biomarker of PCa aggressiveness. Prostate © 2013 Wiley Periodicals, Inc.</description>
<date>2013-03-26</date>
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