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<title lang=en>Evolutionary Story of Mammalian-specific Amelogenin Exons 4, ``4b'', 8, and 9</title>
<creator>Sire, J. -Y.</creator>
<creator>Huang, Y.</creator>
<creator>Li, W.</creator>
<creator>Delgado, S.</creator>
<creator>Goldberg, M.</creator>
<creator>DenBesten, P. K.</creator>
<contributor>Evolution et développement du squelette (EDS) ; Systématique, adaptation, évolution (SAE) ; Centre National de la Recherche Scientifique (CNRS) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Evolution Paris Seine ; Université des Antilles et de la Guyane (UAG) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Centre National de la Recherche Scientifique (CNRS) - Université des Antilles et de la Guyane (UAG) - Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA)</contributor>
<contributor>Centre National de la Recherche Scientifique</contributor>
<contributor> Universite Pierre et Marie Curie [UMR7138]</contributor>
<description>International audience</description>
<source>ISSN: 0022-0345</source>
<source>Journal of Dental Research</source>
<publisher>SAGE Publications (UK and US)</publisher>
<identifier>hal-01545487</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01545487</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01545487</source>
<source>Journal of Dental Research, SAGE Publications (UK and US), 2012, 91 (1), pp.84-89. 〈10.1177/0022034511423399〉</source>
<identifier>DOI : 10.1177/0022034511423399</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1177/0022034511423399</relation>
<language>en</language>
<subject lang=en>amelogenin</subject>
<subject lang=en> small exons</subject>
<subject lang=en> evolutionary origin</subject>
<subject lang=en> PCR</subject>
<subject lang=en> enamel</subject>
<subject lang=en> tetrapods</subject>
<subject>[SDV.BID.EVO] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Amelogenin gene organization varies from 6 exons (1,2,3,5,6,7) in amphibians and sauropsids to 10 in rodents. The additional exons are exons 4, 8, 9, and ``4b'', the latter being as yet unidentified in AMELX transcripts. To learn more about the evolutionary origin of these exons, we used an in silico approach to find them in 39 tetrapod genomes. AMEL organization with 6 exons was the ancestral condition. Exon 4 was created in an ancestral therian (marsupials + placentals), then exon 9 in an ancestral placental, and finally exons ``4b'' and 8 in rodents, after divergence of the squirrel lineage. These exons were either inactivated in some lineages or remained functional: Exon 4 is functional from artiodactyls onward; exon 9 is known, to date, only in rodents, but could be coding in various mammals; and exon ``4b'' was probably coding in some rodents. We performed PCR of cDNA isolated from mouse and human tooth buds to identify the presence of these transcripts. A sequence analogous to exon ``4b'', and to exon 9, could not be amplified from the respective tooth cDNA, indicating that even though sequences similar to these exons are present, they are not transcribed in these species.</description>
<date>2012-01</date>
</dc>
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