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<title lang=en>Exposures of zebrafish through diet to three environmentally relevant mixtures of PAHs produce behavioral disruptions in unexposed F1 and F2 descendant.</title>
<creator>Vignet, Caroline</creator>
<creator>Joassard, Lucette</creator>
<creator>Lyphout, Laura</creator>
<creator>Guionnet, Tiphaine</creator>
<creator>Goubeau, Manon</creator>
<creator>Le Menach, Karyn</creator>
<creator>Brion, François</creator>
<creator>Kah, Olivier</creator>
<creator>Chung, Bon-Chu</creator>
<creator>Budzinski, Hélène</creator>
<creator>Bégout, Marie-Laure</creator>
<creator>Cousin, Xavier</creator>
<contributor>Laboratoire d'ecotoxicologie ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)</contributor>
<contributor>Laboratoire des Ressources Halieutiques (IFREMER) ; Département Systèmes Sous-Marins - IFREMER ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) - Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)</contributor>
<contributor>UMR 5805 Environnements et Paléoenvironnements Océaniques et Continentaux (EPOC) ; Observatoire aquitain des sciences de l'univers (OASU) ; Université Sciences et Technologies - Bordeaux 1 - Institut national des sciences de l'Univers (INSU - CNRS) - Centre National de la Recherche Scientifique (CNRS) - Université Sciences et Technologies - Bordeaux 1 - Institut national des sciences de l'Univers (INSU - CNRS) - Centre National de la Recherche Scientifique (CNRS) - École pratique des hautes études (EPHE) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut National de l'Environnement Industriel et des Risques (INERIS)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institute of Molecular Biology (IMB Sinica) ; Academia Sinica</contributor>
<contributor>Laboratoire de Physiologie et Génomique des Poissons (LPGP) ; Institut National de la Recherche Agronomique (INRA) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>This study was supported financially by the ANR project ConPhyPoP (CES 09_002) and CPER A2E. This later project is co-financed by the European Union with the European fund of regional development. A doctoral grant was received from the Région Poitou-Charentes and froml’Institut Français de Recherche pour l’Exploitation de la Mer (C.V.). This work was part of the LABEX COTE cluster of excellence "Continental to coastal ecosystems".</contributor>
<description>International audience</description>
<source>ISSN: 0944-1344</source>
<source>EISSN: 1614-7499</source>
<source>Environmental Science and Pollution Research</source>
<publisher>Springer Verlag</publisher>
<identifier>hal-01121865</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01121865</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01121865/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01121865/file/Exposures%20of%20zebrafish_accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01121865</source>
<source>Environmental Science and Pollution Research, Springer Verlag, 2015, 22 (21), pp.16371-16383. 〈10.1007/s11356-015-4157-8〉</source>
<identifier>DOI : 10.1007/s11356-015-4157-8</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1007/s11356-015-4157-8</relation>
<identifier>PUBMED : 25639250</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25639250</relation>
<language>en</language>
<subject lang=en>anxiety-like behavior</subject>
<subject lang=en>photomotor response</subject>
<subject lang=en>heavy oil</subject>
<subject lang=en>light crude oil</subject>
<subject lang=en>locomotor activity</subject>
<subject lang=en>Danio rerio</subject>
<subject lang=en>polycyclic aromatic hydrocarbon</subject>
<subject lang=en>offspring</subject>
<subject lang=en>transgenerational effect</subject>
<subject>[SDV.EE] Life Sciences [q-bio]/Ecology, environment</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The release of polycyclic aromatic hydrocarbons (PAHs) into the environment has increased very substantially over the last decades. PAHs are hydrophobic molecules which can accumulate in high concentrations in sediments acting then as major secondary sources. Fish contamination can occur through contact or residence nearby sediments or though dietary exposure. In this study, we analyzed certain physiological traits in unexposed fish (F1) issued from parents (F0) exposed through diet to three PAH mixtures at similar and environmentally relevant concentrations but differing in their compositions. For each mixture, no morphological differences were observed between concentrations. An increase in locomotor activity was observed in larvae issued from fish exposed to the highest concentration of a pyrolytic (PY) mixture. On the contrary, a decrease in locomotor activity was observed in larvae issued from heavy oil mixture (HO). In the case of the third mixture, light oil (LO), a reduction of the diurnal activity was observed during the setup of larval activity. Behavioral disruptions persisted in F1-PY juveniles and in their offspring (F2). Endocrine disruption was analyzed using cyp19a1b:GFP transgenic line and revealed disruptions in PY and LO offspring. Since no PAH metabolites were dosed in larvae, these findings suggest possible underlying mechanisms such as altered parental signaling molecule and/or hormone transferred in the gametes, eventually leading to early imprinting. Taken together, these results indicate that physiological disruptions are observed in offspring of fish exposed to PAH mixtures through diet.</description>
<date>2015-02-03</date>
</dc>
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