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<identifier>oai:HAL:hal-01668327v1</identifier>
<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Effects of hydroxyurea on blood rheology in sickle cell anemia: A two-years follow-up study</title>
<creator>Lemonne, Nathalie</creator>
<creator>Möckesch, Berenike</creator>
<creator>Charlot, Keyne</creator>
<creator>Garnier, Yohann</creator>
<creator>Waltz, Xavier</creator>
<creator>Lamarre, Yann</creator>
<creator>Antoine-Jonville, Sophie</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Romana, Marc</creator>
<creator>Connes, Philippe</creator>
<contributor>Unité Transversale de la Drépanocytose ; CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Université des Antilles (Pôle Guadeloupe) ; Université des Antilles (UA)</contributor>
<contributor>Biologie intégrée du globule rouge ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Biologie Intégrée du Globule Rouge ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre</contributor>
<contributor>Dynamique des Structures et Interactions des Macromolécules Biologiques- Pôle de La Réunion (DSIMB Réunion) ; Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB) ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de la Réunion (UR)</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<description>International audience</description>
<source>ISSN: 1386-0291</source>
<source>Clinical Hemorheology and Microcirculation</source>
<publisher>IOS Press</publisher>
<identifier>hal-01668327</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668327</identifier>
<source>https://hal.univ-antilles.fr/hal-01668327</source>
<source>Clinical Hemorheology and Microcirculation, IOS Press, 2017, 67 (2), pp.141 - 148. 〈10.3233/CH-170280〉</source>
<identifier>DOI : 10.3233/CH-170280</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.3233/CH-170280</relation>
<language>en</language>
<subject lang=en>Hydroxyurea</subject>
<subject lang=en> blood rheology</subject>
<subject lang=en> clinical severity</subject>
<subject lang=en> sickle cell disease</subject>
<subject>[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The aim of the present study was to test the effects of hydroxyurea (HU) therapy on clinical, hematological and hemorheological parameters in adult patients with sickle cell anemia (SCA). Hematological and hemorheological parameters were measured in 28 SCA patients before HU therapy (i.e., baseline) and at 6, 12 and 24 months of treatment. RBC deformability was determined by ektacytometry at 30 Pa. RBC aggregation properties were investigated by light-backscatter method. Blood viscosity was measured at 225 s-1 by a cone-plate viscometer. The rates of vaso-occlusive crises and acute chest syndrome were lower at 1 and 2 years of HU therapy compared to baseline. The proportion of patients with leg ulcers tended to decrease after 2 years of treatment. Hemoglobin oxygen saturation improved with HU therapy. HU therapy induced a decrease of platelet and white blood cell counts and a rise in fetal hemoglobin level and mean cell volume. While hemoglobin concentrations increased under HU, blood viscosity remained unchanged all along the study. RBC deformability increased over baseline values at 6 months of HU therapy and continued to rise until the end of the follow-up period. In conclusion, the improvement in RBC deformability probably compensates the increase of hemoglobin on blood viscosity and participates to the improvement of the clinical status of patients.</description>
<date>2017-11-16</date>
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