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<publisher>HAL CCSD</publisher>
<title lang=en>Effects of phlebotomy therapy on cytochrome P450 2e1 activity and oxidative stress markers in dysmetabolic iron overload syndrome: a randomized trial.</title>
<creator>Lainé, F.</creator>
<creator>Reymann, J. M.</creator>
<creator>Morel, Fabrice</creator>
<creator>Langouët, Sophie</creator>
<creator>Perrin, M.</creator>
<creator>Guillygomarc'H, A.</creator>
<creator>Brissot, Pierre</creator>
<creator>Turmel, V.</creator>
<creator>Mouchel, C.</creator>
<creator>Pape, D.</creator>
<creator>Bellissant, E.</creator>
<creator>Deugnier, Y.</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Détoxication et réparation tissulaire ; Université de Rennes 1 (UR1) - IFR140 - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Signalisation et Réponses aux Agents Infectieux et Chimiques (SeRAIC) ; Université de Rennes 1 (UR1) - IFR140</contributor>
<contributor>Foie, métabolismes et cancer ; Université de Rennes 1 (UR1) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Programme Hospitalier de Recherche Clinique (2002)</contributor>
<description>International audience</description>
<source>ISSN: 0269-2813</source>
<source>EISSN: 1365-2036</source>
<source>Alimentary Pharmacology and Therapeutics</source>
<publisher>Wiley</publisher>
<identifier>hal-00702125</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00702125</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00702125</source>
<source>Alimentary Pharmacology and Therapeutics, Wiley, 2006, 24 (8), pp.1207-13. 〈10.1111/j.1365-2036.2006.03116.x〉</source>
<identifier>DOI : 10.1111/j.1365-2036.2006.03116.x</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2036.2006.03116.x</relation>
<identifier>PUBMED : 17014579</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/17014579</relation>
<language>en</language>
<subject>[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>AIM: To assess the effects of iron removal on cytochrome P450 2E1 activity and oxidative stress in dysmetabolic iron overload syndrome. METHODS: Forty-eight patients were randomized to phlebotomy therapy consisting of removal of 300-500 mL of blood every 14 days until serum ferritin levels dropped under 100 microg/L or to follow-up without phlebotomy therapy. Cytochrome P450 2E1 activity was measured at baseline and at the end of treatment by using the 6-hydroxychlorzoxazone/chlorzoxazone blood metabolic ratio, 2 h after the intake of 500 mg of chlorzoxazone. RESULTS: In the treatment group, a mean of 3.9 +/- 1.3 L of blood was removed and serum ferritin levels dropped from 715 +/- 397 to 74 +/- 34 microg/L. Variation of cytochrome P450 2E1 activity was not significantly different between the 2 groups (0.07 +/- 0.26 vs. 0.03 +/- 0.19, P = 0.36). In the treatment group, low-density lipoprotein cholesterol and vitamin E were lowered after treatment compared with control group (-0.15 +/- 0.51 vs. 0.24 +/- 0.58, P = 0.002 and -1.3 +/- 4.4 vs. 2.3 +/- 5.2, P = 0.03, respectively). Inversely, vitamin C was increased (0.5 +/- 3.5 vs. -1.8 +/- 3.9, P = 0.03). CONCLUSIONS: In dysmetabolic iron overload syndrome, reduction of iron stores does not significantly influence cytochrome P450 2E1 activity but is associated with a significant decrease of low-density lipoprotein cholesterol, suggesting that venesection therapy may be a suitable option in these patients.</description>
<date>2006-10-15</date>
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