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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Efficacy in the treatment of malaria by Plasmodium vivax in Oiapoque, Brazil, on the border with French Guiana: the importance of control over external factors.</title>
<creator>Gomes, Margarete do Socorro M</creator>
<creator>Vieira, José Luiz F</creator>
<creator>Machado, Ricardo L D</creator>
<creator>Nacher, Mathieu</creator>
<creator>Stefani, Aurélia</creator>
<creator>Musset, Lise</creator>
<creator>Legrand, Eric</creator>
<creator>Menezes, Rubens A O</creator>
<creator>Júnior, Aldo A P</creator>
<creator>Sousa, Ana P M</creator>
<creator>Couto, Vanja S C D Almeida</creator>
<creator>Couto, Álvaro A R D'Almeida</creator>
<contributor>Federal University of Para - Universidade Federal do Para [Belem - Brésil]</contributor>
<contributor>Laboratório Central de Saúde Pública do Amapá (LACEN-AP) ; Gerência de Pesquisa e Desenvolvimento Institucional - Saúde Pública</contributor>
<contributor>Evendro Chagas Institut</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Laboratoire de Parasitologie ; Institut Pasteur de la Guyane - Réseau International de Instituts Pasteur</contributor>
<contributor>Federal University of Amapà</contributor>
<contributor>Amapa State Health Department</contributor>
<contributor>Work reported in this manuscript was funded by the National Scientific and Technological Development in the Research Program for Health System Unique (CNPq PPSUS Public Notice No. 00077/2008/MCT/CNPq/SETEC, Process No. 35.000.162/2009), the Government of the State of Amapá, and the Central Public Health Laboratory of Amapá.</contributor>
<description>International audience</description>
<source>ISSN: 1475-2875</source>
<source>Malaria Journal</source>
<publisher>BioMed Central</publisher>
<identifier>pasteur-01229355</identifier>
<identifier>https://hal-pasteur.archives-ouvertes.fr/pasteur-01229355</identifier>
<identifier>https://hal-pasteur.archives-ouvertes.fr/pasteur-01229355/document</identifier>
<identifier>https://hal-pasteur.archives-ouvertes.fr/pasteur-01229355/file/s12936-015-0925-7.pdf</identifier>
<source>https://hal-pasteur.archives-ouvertes.fr/pasteur-01229355</source>
<source>Malaria Journal, BioMed Central, 2015, 14 (1), pp.402. 〈10.1186/s12936-015-0925-7〉</source>
<identifier>PUBMEDCENTRAL : PMC4600333</identifier>
<identifier>PUBMED : 26453152</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26453152</relation>
<identifier>DOI : 10.1186/s12936-015-0925-7</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1186/s12936-015-0925-7</relation>
<language>en</language>
<subject lang=en>Malaria</subject>
<subject lang=en>Plasmodium vivax</subject>
<subject lang=en>Anti-malarials</subject>
<subject lang=en>Treatment efficacy</subject>
<subject lang=en>Brazil-French Guiana border</subject>
<subject lang=en>External factors</subject>
<subject lang=en>Treatment failure</subject>
<subject>[SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Plasmodium vivax malaria is an important public health issue in the Amazon region, and it accounts for approximately 84 % of cases of the disease. Migration across the border between Brazil and French Guiana contributes to the maintenance of the disease. The aim of this study was to evaluate the therapeutic and parasitological responses of patients with P. vivax malaria treated with chloroquine and primaquine in the socio-environmental context of cross-border interactions between Brazil and French Guiana. The factors controlled were diagnostic agreement, adherence, adjustment of primaquine doses for patient weight, and quality of the drugs used. A prospective study was conducted in 2011 with 103 individuals aged 10-60 years with a positive diagnosis of P. vivax treated with chloroquine (10 mg base/kg on the first day, followed by 7.5 mg/kg on the second and third days) and primaquine for 7 days, who were followed for 28 days. The primaquine doses were adjusted for the patients' weight. A number of factors were determined: epidemiological characteristics, origin of patients, signs and symptoms, initial parasitaemia and parasitaemia clearance time, blood concentrations of chloroquine and primaquine, quality of anti-malarial drugs and diagnostic agreement. Ninety-five patients were followed for 28 days. There was a 100 % agreement in microscopic diagnosis between field laboratory and reference centre. The adhesion to the treatment was 100 %. Of these patients, 32.6 % received a weight-adjusted dose of primaquine. The chloroquine and primaquine tablets were consistent with the optimal quality limits for human consumption. The investigated patients achieved optimal blood exposure to anti-malarial drugs. The parasitological and therapeutic response was adequate in 99.0 % of cases. In the municipality of Oiapoque, the therapeutic regime used for the treatment of P. vivax malaria using chloroquine combined with primaquine remains effective, when external factors are controlled, such as the quality of anti-malarial drugs, the adhesion to the treatment prescribed, the correct diagnostic and the adjustment of primaquine dose for patient body weight.</description>
<rights>http://creativecommons.org/licenses/by/</rights>
<date>2015-10-09</date>
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