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<title lang=en>The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine</title>
<creator>Gély-Pernot, Aurore</creator>
<creator>Hao, Chunxiang</creator>
<creator>Becker, Emmanuelle</creator>
<creator>Stuparevic, Igor</creator>
<creator>Kervarrec, Christine</creator>
<creator>Chalmel, Frédéric</creator>
<creator>Primig, Michael</creator>
<creator>Jégou, Bernard</creator>
<creator>Smagulova, Fatima</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>University of Zagreb</contributor>
<contributor>École des Hautes Études en Santé Publique [EHESP] (EHESP)</contributor>
<description>International audience</description>
<source>ISSN: 1471-2164</source>
<source>BMC Genomics</source>
<publisher>BioMed Central</publisher>
<identifier>hal-01225493</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01225493</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01225493</source>
<source>BMC Genomics, BioMed Central, 2015, 16 (1), pp.885. 〈10.1186/s12864-015-2095-y〉</source>
<identifier>DOI : 10.1186/s12864-015-2095-y</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1186/s12864-015-2095-y</relation>
<identifier>PUBMED : 26518232</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26518232</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Environmental factors such as pesticides can cause phenotypic changes in various organisms, including mammals. We studied the effects of the widely used herbicide atrazine (ATZ) on meiosis, a key step of gametogenesis, in male mice. METHODS: Gene expression pattern was analysed by Gene-Chip array. Genome-wide mapping of H3K4me3 marks distribution was done by ChIP-sequencing of testis tissue using Illumina technologies. RT-qPCR was used to validate differentially expressed genes or differential peaks. RESULTS: We demonstrate that exposure to ATZ reduces testosterone levels and the number of spermatozoa in the epididymis and delays meiosis. Using Gene-Chip and ChIP-Seq analysis of H3K4me3 marks, we found that a broad range of cellular functions, including GTPase activity, mitochondrial function and steroid-hormone metabolism, are affected by ATZ. Furthermore, treated mice display enriched histone H3K4me3 marks in regions of strong recombination (double-strand break sites), within very large genes and reduced marks in the pseudoautosomal region of X chromosome. CONCLUSIONS: Our data demonstrate that atrazine exposure interferes with normal meiosis, which affects spermatozoa production</description>
<date>2015</date>
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