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<identifier>oai:HAL:inserm-01408935v1</identifier>
<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>EVALUATION OF CIRCUMSPOROZOITE PROTEIN OF Plasmodium vivax TO ESTIMATE ITS PREVALENCE IN OIAPOQUE, AMAPÁ STATE, BRAZIL, BORDERING FRENCH GUIANA</title>
<creator>Gomes, Margarete do Socorro Mendonça</creator>
<creator>VIEIRA, José Luiz Fernandes</creator>
<creator>CASSIANO, Gustavo Capatti</creator>
<creator>Musset, Lise</creator>
<creator>Legrand, Eric</creator>
<creator>Nacher, Mathieu</creator>
<creator>COUTO, Vanja Suely Calvosa D'Almeida</creator>
<creator>MACHADO, Ricardo Luiz Dantas</creator>
<creator>COUTO, Álvaro Augusto Ribeiro D'Almeida</creator>
<contributor>Laboratório Central de Saúde Pública do Amapa ; Laboratório Central de Saúde Pública do Amapa</contributor>
<contributor>Federal University of Para - Universidade Federal do Para [Belem - Brésil]</contributor>
<contributor>Universidade Estadual Paulista Júlio de Mesquita (UNESP)</contributor>
<contributor>Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane ; Institut Pasteur de la Guyane - Réseau International des Instituts Pasteur (RIIP) - WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Secretaria de Estado da Saúde do Amapá. Macapá, Amapá State, Brazil</contributor>
<contributor>Instituto Evandro Chagas</contributor>
<contributor>National Scientific and Technological Development in the Research Program for Health System Unique (CNPq PPSUS Public Notice No. 00077/2008/MCT/CNPq/SETEC, Process No. 35.000.162/2009) Government of the State of Amapá Central Public Health Laboratory (LACEN) of Amapá.</contributor>
<description>International audience</description>
<source>ISSN: 0036-4665</source>
<source>EISSN: 1678-9946</source>
<source>Revista do Instituto de Medicina Tropical de São Paulo</source>
<publisher>Instituto de Medicina Tropical</publisher>
<identifier>inserm-01408935</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01408935</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01408935/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01408935/file/2016%2C%20Gomes%20-%20Evaluation%20of%20circumsporozoite%20protein%20of%20Plasmodium%20vivax.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-01408935</source>
<source>Revista do Instituto de Medicina Tropical de São Paulo, Instituto de Medicina Tropical, 2016, 58, pp.72. 〈10.1590/S1678-9946201658072〉</source>
<identifier>DOI : 10.1590/S1678-9946201658072</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1590/S1678-9946201658072</relation>
<identifier>PUBMED : 27680177</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27680177</relation>
<language>en</language>
<subject lang=en>Plasmodium vivax</subject>
<subject lang=en>Circumsporozoite protein</subject>
<subject lang=en>Brazil–French Guiana border</subject>
<subject lang=en>Genetic marker</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Malaria is a major health problem for people who live on the border between Brazil and French Guiana. Here we discuss Plasmodium vivax distribution pattern in the town of Oiapoque, Amapá State using the circumsporozoite (CS) gene as a marker. Ninety-one peripheral blood samples from P. vivax patients have been studied. Of these, 64 individuals were from the municipality of Oiapoque (Amapá State, Brazil) and 27 patients from French Guiana (August to December 2011). DNA extraction was performed, and a fragment of the P. vivax CS gene was subsequently analyzed using PCR/RFLP. The VK210 genotype was the most common in both countries (48.36% in Brazil and 14.28% in French Guiana), followed by the P. vivax-like (1.10% in both Brazil and French Guiana) and VK247 (1.10% only in Brazil) in single infections. We were able to detect all three CS genotypes simultaneously in mixed infections. There were no statistically significant differences either regarding infection site or parasitaemia among individuals with different genotypes. These results suggest that the same genotypes circulating in French Guiana are found in the municipality of Oiapoque in Brazil. These findings suggest that there may be a dispersion of parasitic populations occurring between the two countries. Most likely, this distribution is associated with prolonged and/or more complex transmission patterns of these genotypes in Brazil, bordering French Guiana.</description>
<date>2016-09-22</date>
</dc>
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