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<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd> <responseDate>2018-01-15T18:29:36Z</responseDate> <request identifier=oai:HAL:hal-01159375v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request> <GetRecord> <record> <header> <identifier>oai:HAL:hal-01159375v1</identifier> <datestamp>2017-12-22</datestamp> <setSpec>type:COMM</setSpec> <setSpec>subject:sdv</setSpec> <setSpec>collection:UNIV-RENNES1</setSpec> <setSpec>collection:M2S</setSpec> <setSpec>collection:BIOSIT</setSpec> <setSpec>collection:UNIV-AG</setSpec> <setSpec>collection:UNIV-BREST</setSpec> <setSpec>collection:INRA</setSpec> <setSpec>collection:IRSET</setSpec> <setSpec>collection:IFR140</setSpec> <setSpec>collection:UR2-HB</setSpec> <setSpec>collection:UR1-UFR-SVE</setSpec> <setSpec>collection:STATS-UR1</setSpec> <setSpec>collection:ENS-CACHAN</setSpec> <setSpec>collection:UR1-HAL</setSpec> <setSpec>collection:UR1-SDV</setSpec> <setSpec>collection:UR1-SHS</setSpec> <setSpec>collection:EHESP</setSpec> <setSpec>collection:USPC</setSpec> <setSpec>collection:UNIV-RENNES2</setSpec> <setSpec>collection:UNIV-ANGERS</setSpec> </header> <metadata><dc> <publisher>HAL CCSD</publisher> <title lang=en>Effects of Galacto-oligosaccharides (GOS) on inflammatory reponse, glycoxidation markers and glycogen content in streptozotocin-diabetic rats.</title> <creator>Lefeuvre-Orfila, Luz</creator> <creator>Vincent, Sophie</creator> <creator>Groussard, Carole</creator> <creator>Saligaut, Dany</creator> <creator>Efstathiou, Theo</creator> <creator>Gratas-Delamarche, Arlette</creator> <contributor>Station commune de Recherches en Ichtyophysiologie, Biodiversité et Environnement (SCRIBE) ; Institut National de la Recherche Agronomique (INRA) - IFR140</contributor> <contributor>Détoxication et réparation tissulaire ; Université de Rennes 1 (UR1) - IFR140 - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor> <contributor>Laboratoire Mouvement Sport Santé (M2S) ; École normale supérieure - Cachan (ENS Cachan) - Université de Rennes 1 (UR1) - Université de Brest (UBO) - Université de Rennes 2 (UR2) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor> <contributor>laboratoire de physiologie et de biomécanique de l'exercice musculaire (UFRAPS) ; Université de Rennes 2 (UR2)</contributor> <contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor> <description>International audience</description> <source>5e congrès international de "Nutrition, Oxygen Biology and Medicine", Paris 5-7 juin 2013</source> <coverage>Paris, France</coverage> <identifier>hal-01159375</identifier> <identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01159375</identifier> <source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01159375</source> <source>5e congrès international de "Nutrition, Oxygen Biology and Medicine", Paris 5-7 juin 2013, 2013, Paris, France. 2013</source> <language>en</language> <subject>[SDV] Life Sciences [q-bio]</subject> <type>info:eu-repo/semantics/conferenceObject</type> <type>Conference papers</type> <description lang=en>Introduction: Diabetes mellitus results from the loss of tolerance to insulin and alters glycemia and the glycogen content. Oxidative stress and inflammation are linked to theses alterations, especially with insulin-resistance. The therapy management of diabetes includes nutritional recommendations. Several nutrients are developed to improve glycemia, oxidative stress, inflammation and glycogen content. More interestingly, ?-GOS exhibits anti-inflammatory and insulin-sensitive effects in vitro (Efstathiou and Fathi 2010) and in vivo (Boucher et al. 2003). Thus, ?-GOS is a potential functional food for the treatment of diabetes. But, less is known about the in vivo effect of ?-GOS on inflammatory, glycoxidation markers and glycogen content in diabetes. In this context, the aim of this work was to study the effect of ?-GOS developed by Sojasun technologies (from fermented soy product) compared to a synthetic ?-GOS produced by Sigma on inflammatory, glycoxidation markers and glycogen content in a streptozotocin-induced diabetic rat model. Methods: Twenty-four male Wistar streptozotocin-diabetic rat (STZ) were divided into three group: control group, supplemented with natural ?-GOS (20 mg/kg/day) group and supplemented with synthetic ?-GOS (20 mg/kg/day). The supplementation protocol duration was 8 weeks. At the end of the protocol, blood and skeletal muscle (gastrocnemius) were obtained to measure glucose , insulin, fructosamine in plasma and N-(carboxymethyl)lysine, glycogen synthase activity and glycogen content, in muscle. Results-Discussion: Diabetes was confirmed with the measure of insuline and glucose levels. All the diabetic groups had significantly higher glucose and insuline levels compared to control healthy group (data not shown). Insuline level in plasma and storage of glycogen in muscle were increased only in both ?-GOS groups. Fructosamine, TNF?and glycogen synthase activity was also decreased in the two supplemented groups (synthetic ?-GOS and natural ?-GOS). CML remained unchanged in all groups. Natural ?-OGT and synthetic ?-OGT only differed on muscular glucose level: only natural ?-OGT induced a significant decrease in muscular glucose. To conclude, our results suggest that ?-GOS alters positively glucose level, increases the glycogen content in diabetique population, improves glycemic control in the long term and decreases the inflammatory effects in streptozotocin-diabetic rat . Keywords: ?-GOS, inflammatory and glycoxidation markers, diabetes. Acknowledgment : Brittany region References Efstathiou, T. and D. Fathi. Sojasun Technologies. 2010 Boucher J et al. J Physiol Biochem. 59(3):169-73, 2003</description> <date>2013</date> </dc> </metadata> </record> </GetRecord> </OAI-PMH>