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<identifier>oai:HAL:inserm-00922110v1</identifier>
<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia.</title>
<creator>Waltz, Xavier</creator>
<creator>Romana, Marc</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Lamarre, Yann</creator>
<creator>Divialle-Doumdo, Lydia</creator>
<creator>Petras, Marie</creator>
<creator>Tarer, Vanessa</creator>
<creator>Hierso, Régine</creator>
<creator>Baltyde, Kizzy-Clara</creator>
<creator>Tressières, Benoît</creator>
<creator>Lalanne-Mistrih, Marie-Laure</creator>
<creator>Maillard, Fréderic</creator>
<creator>Hue, Olivier</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Connes, Philippe</creator>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Laboratory of Excellence GR-Ex "The red cell: from genesis to death" ; PRES Sorbonne Paris Cité</contributor>
<contributor>Unité Transversale de la Drépanocytose ; Hôpital Ricou - CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre de référence maladies rares pour la drépanocytose aux Antilles-Guyane ; Centre Hospitalier et Universitaire de Pointe-à-Pitre</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Service de Pédiatrie ; Centre Hospitalier et Universitaire de Pointe-à-Pitre</contributor>
<contributor>Institut Universitaire de France (IUF) ; Ministère de l'Éducation nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)</contributor>
<contributor>"Projet Hospitalier de Recherche Clinique Interregional" (PHRC). X.W. thesis was funded by the regional council of Guadeloupe.</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>inserm-00922110</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00922110</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00922110/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00922110/file/2013_Waltz_-_Hematological_and_hemorheological_determinants_6_minutes.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00922110</source>
<source>PLoS ONE, Public Library of Science, 2013, 8 (10), pp.e77830. 〈10.1371/journal.pone.0077830〉</source>
<identifier>DOI : 10.1371/journal.pone.0077830</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0077830</relation>
<identifier>PUBMED : 24147086</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24147086</relation>
<language>en</language>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The six-minute walk test is a well-established submaximal exercise reflecting the functional status and the clinical severity of sickle cell patients. The aim of the present cross-sectional study was to investigate the biological determinants of the six-minute walk test performance in children with sickle cell anemia. Hematological and hemorheological parameters, pulmonary function and the six-minute walk test performance were determined in 42 children with sickle cell anemia at steady state. The performance during the six-minute walk test was normalized for age, sex and height and expressed as percentage of the predicted six-minute walk distance. We showed that a high level of anemia, a low fetal hemoglobin expression and low red blood cell deformability were independent predictors of a low six-minute walk test performance. This study describes for the first time the impact of blood rheology in the six-minute walk test performance in children with sickle cell anemia.</description>
<date>2013</date>
</dc>
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