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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>HIV-1 Pol Gene Polymorphism and Antiretroviral Resistance Mutations in Treatment-Naive Adult Patients in French Guiana Between 2006 and 2012</title>
<creator>Darcissac, Edith</creator>
<creator>Nacher, Mathieu</creator>
<creator>Adriouch, Leila</creator>
<creator>Berlioz-Arthaud, Alain</creator>
<creator>Boukhari, Rachida</creator>
<creator>Couppié, Pierre</creator>
<creator>Djossou, Felix</creator>
<creator>Donato, Damien</creator>
<creator>Guedj, Myriam, </creator>
<creator>Lavergne, Anne</creator>
<creator>Papot, Emmanuelle</creator>
<creator>Pouliquen, Jean-François</creator>
<creator>Tanguy, Edouard</creator>
<creator>Vantilcke, Vincent</creator>
<creator>Lacoste, Vincent</creator>
<contributor>Institut Pasteur de la Guyane Française ; Institut Pasteur de la Guyane - Réseau International des Instituts Pasteur (RIIP)</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Centre Hospitalier de l'Ouest Guyanais Franck Joly (Saint-Laurent-du-Maroni) </contributor>
<contributor>Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française] ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>This work was funded by the Institut Pasteur de la Guyane. It has also benefited from a European commission REGPOT-CT-2011-285837-STRonGer grant within the FP7</contributor>
<description>International audience</description>
<source>ISSN: 0889-2229</source>
<source>EISSN: 0889-2229</source>
<source>AIDS Research and Human Retroviruses</source>
<publisher>Mary Ann Liebert</publisher>
<identifier>pasteur-01583613</identifier>
<identifier>https://hal-riip.archives-ouvertes.fr/pasteur-01583613</identifier>
<identifier>https://hal-riip.archives-ouvertes.fr/pasteur-01583613/document</identifier>
<identifier>https://hal-riip.archives-ouvertes.fr/pasteur-01583613/file/2016%20Darcissac%20et%20al.%20ARHR.pdf</identifier>
<source>https://hal-riip.archives-ouvertes.fr/pasteur-01583613</source>
<source>AIDS Research and Human Retroviruses, Mary Ann Liebert, 2016, 32 (8), pp.801 - 811. 〈10.1089/aid.2016.0048〉</source>
<identifier>DOI : 10.1089/aid.2016.0048</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1089/aid.2016.0048</relation>
<identifier>PUBMED : 27009561</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27009561</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<subject>[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Little information is available on the molecular epidemiologic profile of HIV-1 in French Guiana, the French department with the highest HIV/AIDS incidence. To follow the evolution of HIV-1 diversity, we carried out a molecular analysis of HIV-1 isolates from 305 treatment-naive patients between 2006 and 2012. Protease and reverse-transcriptase sequences were obtained for subtype characterization, polymorphism analysis, and identification of drug resistance mutations. Of 305 HIV-1 strains, 95.1% were subtype B viruses. The overall prevalence of transmitted drug-resistance mutations (TDRMs) was 4.6% (14/305), ranging from 1.9% to 7.1% depending on the year. This study shows a low level of HIV-1 genetic diversity and a moderate prevalence of TDRMs with no evidence of an increasing trend over the study period. Nevertheless, the strong genetic polymorphism observed on both genes may be of concern for long-term treatment of people living with HIV-1 and thus deserves continuous monitoring.</description>
<date>2016-08</date>
<contributor>European Project : 285837, EC:FP7:REGPOT, FP7-REGPOT-2011-1, STRONGER(2011)</contributor>
<relation>info:eu-repo/grantAgreement/EC/FP7/285837/EU/Strengthening transdisciplinary research on infectious and emerging diseases in French Guiana: linking fieldwork, benchside and bedside/STRONGER</relation>
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