Éditeur(s) : Trembly McDougal, Daniel
Siècle(s) traité(s) : 20
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG18185
ADG18185

Éditeur(s) : CATIE The Rockefeller Foundation CATIE ( Turrialba, Costa Rica ) The Rockefeller Foundation ( New York )
Résumé : "Turrialba, Costa Rica, Diciembre 1 a 5 de 1980."
Conclusions and recommendations from the conference.
Tropics
Latin America
Tropics
Tropics

713037865
ocn713037865

Résumé : (Bibliography) Includes bibliographical references.
(Statement of Responsibility) Peter E. Hildebrand.
Cover title.
"Report of a Five Year Tour of Duty by Peter E. Hildebrand."
"The Rockefeller Foundation, New York, December 1979."
Guatemala
Guatemala
Guatemala

76894442

Éditeur(s) : Sector Publico Agricola, Instituto de Ciencia y Tecnologia Agricolas Sector Publico Agricola, Instituto de Ciencia y Tecnologia Agricolas
Résumé : Cover title.
"Prepared for presentation at the conference on: Integrated Crop and Animal Production to Optimize Resource Utilization on Small Farms in Developing Countries, The Rockefeller Foundation Conference Center, Bellagio, Italy, October 18-23, 1978."
Includes bibliographical references (leaf 12).
(Funding) Electronic resources created as part of a prototype UF Institutional Repository and Faculty Papers project by the University of Florida.
Guatemala
Caribbean
Guatemala
Guatemala

ocm7152

Éditeur(s) : HAL CCSD Rockefeller University Press
Résumé : International audience
Accumulation of type I collagen fibrils in tumors is associated with an increased risk of metastasis. Invadosomes are F-actin structures able to degrade the extracellular matrix. We previously found that collagen I fibrils induced the formation of peculiar linear invadosomes in an unexpected integrin-independent manner. Here, we show that Discoidin Domain Receptor 1 (DDR1), a collagen receptor overexpressed in cancer, colocalizes with linear invadosomes in tumor cells and is required for their formation and matrix degradation ability. Unexpectedly, DDR1 kinase activity is not required for invadosome formation or activity, nor is Src tyrosine kinase. We show that the RhoGTPase Cdc42 is activated on collagen in a DDR1-dependent manner. Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize to linear invadosomes, and both are required for linear invadosome formation. Finally, DDR1 depletion blocked cell invasion in a collagen gel. Altogether, our data uncover an important role for DDR1, acting through Tuba and Cdc42, in proteolysis-based cell invasion in a collagen-rich environment.
ISSN: 0021-9525

hal-01118481
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118481
PUBMED : 25422375
DOI : 10.1083/jcb.201404079
PUBMEDCENTRAL : PMC4242841